2001 Fiscal Year Final Research Report Summary
Thermosensitive polymers prepared from N-vinylacylamide
| Project/Area Number |
10555326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
高分子合成
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| Research Institution | Kagoshima University |
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Principal Investigator |
AKASHI Mitsuru Kagoshima University, Faculty of Engineering, Professor, 工学部, 教授 (20145460)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMIKAWA Hiroshi Mitsubishi Chemical Corporation, Yokohama Research Center, Research Scientist, 横浜総合研究所・機能科学研究所, 副主任研究員
SERIZAWA Takeshi Kagoshima University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (30284904)
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| Project Period (FY) |
1998 – 2001
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| Keywords | thermosensitive polymers / N-vinylacylamides / N -vinylisobutyramide / poly (N-isopropylacrylamide) / polymeric nanosheres / platinum colloids / DDS / LCST behavior |
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| Research Abstract |
We have developed novel thermosensitive polymers consisting of N-vinylacylamides such as N-vinylisobutyramide (NVIBA) and studied their properties and application comparing with poly (N-isopropylacrylamide) (PNIPAAm). First, we synthesized N-vinylacylamide monomers and polymerized using a free radical polymerization technique. After preparing water soluble polymers and cross-linked hydrogels, their thermosensitive properties were studied in comparison with PNIPAAm. It is A found that LCST of PNVIBA is sharply 39 ℃. Dispersion copolymerization of styrene and PNIPAAm or PNVIBA macromonomers gave water dispersible core-corona type polymeric nanospheres by self-assembling mechanism. Platinum and silver colloids were effectively entrapped on the surfaces (that is corona) of thermosensitive polymeric nanospheres to act as catalyst for hydrogenation in case of platinum colloids. When peptides were physically immobilized in corona of nanospheres, this system seemed to be a well-designed oral peptide drug delivery system from the results of animal examinations. Finally, we clarified that commercially available N-vinylformamide or N-vinylacetoamide were copolymerized with vinylacetate to give thermosensitive polymers as well as PNIPAAm and PNVIBA.
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