• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2000 Fiscal Year Final Research Report Summary

The causative genes for allergy and clinical use.

Research Project

Project/Area Number 10557075
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Pediatrics
Research InstitutionGifu University

Principal Investigator

KONDO Naomi  Gifu University School of Medicine, Professor, 医学部, 教授 (50124714)

Project Period (FY) 1998 – 2000
Keywordsatopy / allergy / IL-12 receptor / IL-18 receptor / I ε region / インターロイキン18レセプタ
Research Abstract

The causative genes of allergy have been newly found and have been structurally analyzed.
(1) In B cells
I ε region, S ε region and C ε region of Ig gene have been analyzed in the patients with allergy. As a result, it becomes clear that chromatin of I ε region is more open in the patients with allergy.
(2) In T cells
The mutations of IL-12 receptor β2 chain gene have been identified as one of the causative genes for allergy. Some patients with high levels of IgE production had the mutations of IL-12 receptor β2 chain gene. IL-12 was not able to inhibit IgE production of the patients' peripheral blood mononuclear cells. Therefore, it was indicated that these mutations induced high levels of IgE production and allergic reactions.
Next, the mutations of IL-18 receptor α2 chain gene have been identified as the causative gene for allergy. Some patients with high levels of IgE production had the mutations of IL- 18 receptor α2 chain gene. IL-18 was not able to inhibit IgE production of the patients' peripheral blood mononuclear cells. Therefore, it was indicated that these mutations also induced high levels of IgE production and allergic reactions.
Moreover, we have published the information of structure of IL-18 protein by NMR.
Furthermore, we have published the genetical classification of atopy for clinical or prevention of allergy.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Kaneko H,Kondo N, et al.: "Expression of the BLM gene in human haematopoietic cells."Clin Exp Immunol. 118. 285-289 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tashita H,Kondo N, et al.: "Molecular basis of selective IgG2 deficiency : The mutated membrane-bound from of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings."J Clin Invest. 101. 677-681 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo N, et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders.-6-year follow-up study."Clin Exp Allergy. 28. 1340-1344 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo N, et al.: "Atopy and mutations of IL-12 receptor β2 chain gene."Clin Exp Allergy. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukao T,Kondo N, et al.: "ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells."Blood. 94. 1998-2006 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsui E,Kondo N, et al.: "Mutations of the IL-12 receptor β2 chain gene in some atopic subjects."Biochem Biophy Res Commun. 266. 551-555 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo N, et al.: "Role of IL-12 receptor β2 mutations in development of atopy."Allergy & Clinical Immunology International. 92-94 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 近藤直実: "分子アレルギー学:アトピーとIgE遺伝子"メディカルレビュー社. 599 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko H, Kondo N, et al.: "Expression of the BLM gene in human haematopoietic cells."Clin Exp Immunol. 118. 285-289 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tashita H, Kondo N, et al.: "Molecular basis of selective IgG2 deficiency : The mutated membrane-bound form of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings."J Clin Invest. 101. 677-681 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo N, et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders.-6-year follow-up study."Clin Exp Allergy. 28. 1340-1344 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo N, et al.: "Atopy and mutations of IL-12 receptor β2 chain gene."Clin Exp Allergy. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukao T, Kondo N, et al.: "ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells."Blood. 94. 1998-2006 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsui E, Kondo N, et al.: "Mutations of the IL-12 receptor β2 chain gene in some atopic subjects."Biochem Biophy Res Commun.. 266. 551-555 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo N, et al.: "Role of IL-12 receptor β2 mutations in development of atopy."Allergy & Clinical Immunology International. Supple 1. 92-94 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2002-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi