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2000 Fiscal Year Final Research Report Summary

Development of MR endoscopy : basic and clinical investigations

Research Project

Project/Area Number 10557085
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Radiation science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YAMADA Ichiro  Tokyo Medical and Dental University, Graduate School, Associate Professor, 大学院・医歯学総合研究科, 助教授 (90182518)

Co-Investigator(Kenkyū-buntansha) KUROIWA Toshihiko  Tokyo Medical and Dental University, Medical Research Institute, Associate Professor, 難治疾患研究所, 助教授 (80129832)
Project Period (FY) 1998 – 2000
KeywordsMRI / Endoscopy / MR endoscopy / Phantom / Animals / Spatial resolution / Histopathology
Research Abstract

In an attempt develop MR endoscopy, we performed the following imaging experiments using 1.5-T clinical MR system and 4.7-T experimental MR system : (1)we designed and made new surface and quadrature RF colis for MR endoscopy ; (2)we tested these colis in phantom experiments using various pulse sequences(spin-echo, fast spin-echo, gradient-echo, and fast gradient-echo methods) ; (3)we investigated the spatial resolution, contrast resolution, and time resolution in MR endoscopy ; (4)we imaged various organs of animals using MR endoscopy with various pulse sequences(spin-echo, fast spin-echo, gradient-echo, and fast gradient-echo methods) ; and, (5)we investigated optimal pulse sequence, repetition time, echo time, flip angle, field of view, and matrix size for each organ of animals in MR endoscopy.
We performed MR endoscopy for gastric and esophageal carcinomas and compared the findings with histopathologic findings. MR endoscopy clearly depicted the normal gastric and esophageal walls as several layers, which corresponded well with the histologic layers. In gastric and esophageal carcinomas, the depth of mural invasion visualized with MR endoscopy correlated well with the histologic staging. MR endoscopy showed a high diagnostic accuracy for evaluating the mural invasion of gastric and esophageal carcinomas and thus potentially enabled preoperative histopathologic staging.
We are performing MR endoscopy for many patients with various diseases. Furthermore, we are planning to develop new methods for MR endoscopy and optimize the imaging methods for each organ in MR endoscopy.

  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Ichiro Yamada: "Superficial esophageal carcinoma : an in vitro study of high-resolution MR imaging at 1.5T"Journal of Magnetic Resonance Imaging. 13(2). 617-623 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Yamada: "Early gastric carcinoma : evaluation with high-spatial-resolution MR imaging in vitro"Radiology. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Yamada: "High-resolution turbo MR angiography for diagnosis of moyamoya disease"Stroke. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Norio Yoshino: "Apparent diffusion coefficient in salivary glands and lesions : evaluation with diffusion-weighted SPLICE MR imaging"Radiology. (in press). (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Yamada: "Tumor volume measurements of acoustic neuromas with three-dimensional CISS and conventional spin-echo MR imaging"Journal of Magnetic Resonance Imaging. 12(6). 826-832 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Yamada: "Takayasu arteritis : diagnosis with breath-hold contrast-enhanced three-dimensional MR angiography"Journal of Magnetic Resonance Imaging. 11(5). 481-487 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Yamada: "Year Book of Vascular Surgery"Porter J, ed., Mosby-Year Book, Inc., Chicago. 552 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Yamada: "Year Book of Diagnostic Radiology"Federle, ed., Mosby-Year Book, Inc., Chicago. 569 (1997)

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      「研究成果報告書概要(和文)」より
  • [Publications] Yamada I, Izumi Y, Kawano T, Yoshino N, Tetsumura A, Ohashi K, Shibuya H.: "Superficial esophageal carcinoma : an in vitro study of high-resolution MR imaging at 1.5T."J Magn Reson Imaging.. 13. 225-231 (2001)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Saito N, Takeshita K, Yoshino N, Tetsumura A, Kumagai J, Shibuya H.: "Early gastric carcinoma : evaluation with high-spatial-resolution MR imaging in vitro."Radilogy.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Nakagawa T, Matsushima Y, Shibuya H.: "High-resolution turbo MR angiography for diagnosis of moyamoya disease."Stroke.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshino N, Yamada I, Ohbayashi N, Honda E, Ida M, Kurabayashi T, Maruyama K, Sasaki T.: "Apparent diffusion coefficients in salivary glands and lesions : evaluation with diffusion-weighted SPLICE MR imaging."Radiology.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Tsunoda A, Noguchi Y, Komatsuzaki A, Shibuya H.: "Tumor volume measurements of acoustic neuromas with three-dimensional constructive interference in steady state and conventional spin-echo MR imaging."J Magn Reson Imaging.. 12. 826-832 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Nakagawa T, Himeno Y, Kobayashi Y, Numano F, Shibuya H.Takayasu: "arteritis : diagnosis with breath-hold contract-enhanced three-dimensional MR angiography."J Magn Reson Imaging.. 11. 481-487 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Himeno Y, Matsushima Y, Shibuya H.: "Renal artery lesions in patients with moyamoya disease : angiographic findings."Stroke.. 31. 733-737 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Miyasaka N, Kuroiwa T, Yu ZF, Nagaoka T, Akimoto H, Yamada I, Kubota T, Aso T.: "Cerebral hypoxia-ischemia : discrepancy between apparent diffusion coefficients and histopathologic changes in rats."Radiology.. 215. 199-204 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroiwa T, Yamada I, Endo S, Hakamata Y, Ito U.: "3-Nitropropionic acid preconditioning ameliorates delayed neurological deterioration and infarction after transient focal cerebral ischemia in gerbils."Neurosci Lett.. 283. 145-148 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H.: "Diffusion coefficients in abdominal organs and hepatic lesions : evaluation with intravoxel incoherent motion echo-planar MR imaging."Radiology.. 210. 617-623 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada I, Himeno Y, Nagaoka T, Akimoto H, Matsushima Y, Kuroiwa T, Shibuya H.: "Moyamoya disease : evaluation with diffusion-weighted and perfusion echo-planar MR imaging."Radiology.. 212. 340-347 (1999)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroiwa T, Nagaoka T, Ueki M, Yamada I, Miyasaka N, Akimoto H, Ichinose S, Okeda R, Hirakawa K.: "Correlations between the apparent diffusion coefficient, water content and ultrastructure relating to vasogenic brain edema in cats."J Neurosyrg.. 90. 499-503 (1999)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsumura A, Yoshino N, Yamada I, Sasaki T.: "Head and neck haemangiomas : contrast-enhanced three-dimensional MR angiography."Neuroradiology.. 41. 140-143 (1999)

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      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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