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2000 Fiscal Year Final Research Report Summary

Development of diffusion-weighted ultra-fast magnetic resonance spectroscopic metabolite imaging

Research Project

Project/Area Number 10557088
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

FURUYA Seiichi  Kyoto Prefectural University of Medicine, Faculty of Medicine, Assistant, 医学部, 助手 (10271173)

Co-Investigator(Kenkyū-buntansha) KOSE Katsumi  Tsukuba University, Institute of Physics, Associate Professor, 物理工学系, 助教授 (60186690)
KIZU Osamu  Kyoto Prefectural University of Medicine, Faculty of Medicine, Assistant, 医学部, 助手 (70305598)
NARUSE Shoji  Kyoto Prefectural University of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50106407)
Project Period (FY) 1998 – 2000
KeywordsMR Spectroscopy / MR Spectroscopic Imaging / Ultra-fast MRSI Method / Relaxation time / Brain metabolism / Diffusion Weighted MRS / Echo Planar imaging
Research Abstract

The aim of this research was to develop a diffusion-weighted imaging of brain metabolite by using ultra-fast magnetic resonance imaging (MRSI) methods. We used three different MRI devices ; a 7T high-resolution NMR spectrometer for animal use, a microimaging deice worked in a clinical MRI magnet (MR mics) and a 1.5T clinical MRI scanner. The MR mics was used to transfer the software designed on the high-resolution NMR spectrometer to the clinical scanner. First, we have developed the echo planar imaging (EPI) sequence to get the ultra-fast MRSI (EPI-MRSI). Secondary, we tried to apply this technique to a diffusion-weighted imaging of brain metabolites. Thirdly, we developed the diffusion tensor imaging to get the information of metabolite diffusion.
We successfully developed the EPI-MRSI for human brain on the clinical MRI scanner. Comparing data of EPI-MRSI with conventional MRSI (SE-MRSI), the measurement time was slightly shorter in EPI-MRSI than in SE-MRSI but the spectral resolution was worse in EPI-MRSI.We realized that the more increased signal intensity was necessary to get a marked improvement of measuring time with EPI-MRSI.Also, it is necessary to have the improvement of the signal-intensity to apply this method to the diffusion weighted metabolite imaging.
We could succeed to develop the diffusion tensor imaging by obtaining the Eigenvector mapping, Eigenvalue mapping and fractional anisotropy mapping. These images clearly demonstrate the nerve fiber direction and anisotropy. We will try to apply these methods to get the information of diffusion metabolite in the brain as a next step.
Although there existed many technical difficulty in completing diffusion-weighted EPI-MRSI, it is indispensable to develop this method, because it has a high potentiality to investigate dynamic aspect of brain metabolites and is promising for both experimentally and clinically. In this sense, further research should be continued.

  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 古谷誠一,成瀬昭二,山田恵,木津修,西村恒彦: "MRIによる多角的脳機能評価"新医療. 27・6. 42-45 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T Takegami,C Tanaka,S Naruse et al: "Mismatch between lactate and the apparent diffusion coefficient of water in progressive focal ischemia."NMR in Biomed. (in print). (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] S Morimoto,S Sasaki,Ktakeda,S Furuya,S Naruse et al: "Decrease in Blood Pressure and Sympathetic Nerve Activity by Microvascular Decompression of the Rostal Ventrolateral Medulla in Essential Hypertension"Stroke. 30. 1707-1710 (1999)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中瀬泰然,水野敏樹,高梨芳彰,中島健二,古谷誠一,成瀬昭二: "Proton magnetic resonance spectroscopy (1H-MRS)によりNAAの低下を認めたcorticobasal degenration (CBD)の1例"脳神経. 50. 421-425 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] O Kizu,S Naruse,S Furuya,H Morishita,M Ide,T Maeda,S Ueda: "Application of proton chemical shift imaging in monitoring of gamma knife radiosurgery on brain tumors"Magnetic Resonance Imaging. 16:2. 197-204 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬昭二,田中忠蔵: "Functional MRI"整形・災害外科. 44(印刷中). (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬昭二,古谷誠一,田中忠蔵: "機能的MRI.脳科学ハンドブック:甘利俊一,外山敬介(編)"朝倉書店. 7 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬昭二,古谷誠一,田中忠蔵: "Functional MRI :脳卒中の画像診断"中外医学社. 11 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] Furuya S, Naruse S, Kizu O et al: "The evaluation of brain function by MRI"SINIRYOU. 27 : 6. 42-45 (2001)

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      「研究成果報告書概要(欧文)」より
  • [Publications] T Takegami, , S Naruse et al: "Mismatch between lactate and the apparent diffusion coefficient of water in progressive focal ischemia."NMR in Biomed. (in printing). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S Morimoto, Furuya, S Naruse et al: "Decrease in Blood Pressure and Sympathetic Nerve Activity by Microvascular Decompression of the RostalVentrolateral Medulla in Essential Hypertension"Stroke. 30. 1707-1710 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakase T, Furuya S, Naruse S et al: "A case of corticobasal degeneration by proton magnetic resonance spectroscopy (1H-MRS)"NOUSINKEI. 50. 421-425 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] O Kizu, S Naruse, S Furuya et al: "Application of proton chemical shift imaging in monitoring of gamma knife radiosurgery on brain tumors"Magnetic Resonance Imaging. 16 : 2. 197-204 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naruse S, Tanaka C: "Functional MRI"Seikei/Saigaigeka. (in printing). (2001)

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  • [Publications] Naruse S, Furuya S, Tanaka C: "Functional MRI (in Japanese)"Noukagaku Hand book, Asakurashoten. 55-62 (2001)

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  • [Publications] Naruse S, Furuya S, Tanaka C: "Functional MRI (in Japanese)"Nousottyu no gazousindan, Chugaiigakusha. 138-148

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  • [Publications] Bito Y, Naruse S, et al.: "Fast lactate-dicriminating spectroscopic imaging using J-Coupling in lactate and the broad spectral bandwidth of lipid."In Naruse S (ed) : Ultrafast Magnetic Resonance Imaging, Elsevier. 201-204 (1999)

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  • [Publications] Kimura T, Naruse S, et al.: "Feasibility study of echo planar spectroscopic imaging for 3D 1H-CSI of human brain"In Naruse S (ed) : Ultrafast Magnetic Resonance Imaging, Elsevier. 255-258 (1999)

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  • [Publications] Fukunaga M, Naruse S, et al.: "Clinical application of functional MR imaging localization of the central sulcus"In Naruse S (ed) : Ultrafast Magnetic Resonance Imaging, Elsevier. 157-160 (1999)

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      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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