2000 Fiscal Year Annual Research Report

特発性パーキンソン病に対する淡蒼球外節電気刺激治療の開発

Research Project

Project/Area Number	10557130
Research Institution	Kumamoto University
Principal Investigator	後藤恵熊本大学, 医学部・附属病院, 講師 (50240916)
Co-Investigator(Kenkyū-buntansha)	森岡基浩熊本大学, 医学部・附属病院, 助手 (20295140) 生塩之敬熊本大学, 医学部, 教授 (20028583)
Keywords	Deep brain stimulation / Globus pallidus / Parkinson's disease / Basal Ganglia / Striatum / Movement Disorders / Monkey / Therapy
Research Abstract	カニクイ猿(Cynomolgus monkey)4頭に対して一側頚動脈にMPTP(1.2mg/kg)を間歇的に注入し、慢性パーキンソン病モデルを作成した。症状の発現は経時間依存性であり、4週間後の神経症状評価では、Gash's hemi-parkinsonian primate rating scaleでscore15以上であることを確認した。その後、定位脳手術的に4箇所の電極を有する脳深部刺激装置を設置した。尚、電極挿入部位の確認はレントゲン撮影にて行った。有線で単極刺激を用い解析を行ったが、淡蒼球内節においては高頻度刺激(130-160Hz)、刺激幅(90-100μsec)で,従来のヒトでの効果と同様にパーキンソン症状の改善が得られた。また、淡蒼球外節の低頻度刺激(5Hz)、刺激幅(90-100μsec)では各々の個体において上記のGash's scoreで6-7の改善が得られ、高頻度刺激(130-160Hz)では逆に症状の悪化がみられた。また、2個体においては全身麻酔下で、経心的に潅流固定を行い、電極挿入位置の確認、およびMPTP投与による黒質緻密層のドパミン作動性神経細胞の脱落を確認した。現在、統計処理などを含めてデータの解析をおこなっている。

Research Products
(10 results)

All Other

All Publications (10 results)

[Publications] S.Goto et al.: "Apraxia of lid opening is alleviated by pallidal stimulation in a patient with Parkinson's disease."Europ.J.Neurol.. 7. 337-340 (2000)
[Publications] S.Hasegawa,M.Morioka,S.Goto et al.: "Expression of neuron specific phosphatase, striatal enriched phosphatase (STEP) in reactive astrocytes."Glia. 29. 316-329 (2000)
[Publications] S.Nishikawa,S.Goto et al.: "Temporal sequence of response to unilateral GPi pallidotomy of motor symptoms in Parkinson's disease."Functional Neurosurgery. 39. 62-63 (2000)
[Publications] S.Nishikawa,S.Goto et al.: "Impact of GPi pallidotomy on tremor in Parkinson's disease."Functional Neurosurgery. 39. 64-65 (2000)
[Publications] S.Nishikawa,S.Goto et al.: "Bilateral globus pallidus internus stimulation for Meige syndrome."Functional Neurosurgery. 39. 126-127 (2000)
[Publications] M.Kudo,S.Goto, et al.: "Bilateral thalamic stimulation for Holmes' tremor caused by unilateral brain stem lesion."Movement Disorders. 16. 170-174 (2001)
[Publications] D.Muta,S.Goto et al.: "Bilateral pallidal stimulation for idiopathic segmental axial dystonia advanced from Meiqe syndrome..."Movement Disorders. (in press).
[Publications] S.Goto et al.: "Abolition of post-apoplectic hemichorea by Vo-complex thalamotomy : long-term follow-up study."Movement Disorders. (in press).
[Publications] T.Hamasaki,S.Goto et al.: "Early-generated preplate neurone in the developing telencephalon : Inward miqration into the striatum."Cerebral Cortex. (in press).
[Publications] T.Hamasaki,S.Goto, et al.: "A role of netrin-1 in the development of the subcortical structure striatum : Repulsive action"J.Neurosci.. (in press).

2000 Fiscal Year Annual Research Report

特発性パーキンソン病に対する淡蒼球外節電気刺激治療の開発

Principal Investigator

後藤 恵 熊本大学, 医学部・附属病院, 講師 (50240916)

Research Products

[Publications] S.Goto et al.: "Apraxia of lid opening is alleviated by pallidal stimulation in a patient with Parkinson's disease."Europ.J.Neurol.. 7. 337-340 (2000)

[Publications] S.Hasegawa,M.Morioka,S.Goto et al.: "Expression of neuron specific phosphatase, striatal enriched phosphatase (STEP) in reactive astrocytes."Glia. 29. 316-329 (2000)

[Publications] S.Nishikawa,S.Goto et al.: "Temporal sequence of response to unilateral GPi pallidotomy of motor symptoms in Parkinson's disease."Functional Neurosurgery. 39. 62-63 (2000)

[Publications] S.Nishikawa,S.Goto et al.: "Impact of GPi pallidotomy on tremor in Parkinson's disease."Functional Neurosurgery. 39. 64-65 (2000)

[Publications] S.Nishikawa,S.Goto et al.: "Bilateral globus pallidus internus stimulation for Meige syndrome."Functional Neurosurgery. 39. 126-127 (2000)

[Publications] M.Kudo,S.Goto, et al.: "Bilateral thalamic stimulation for Holmes' tremor caused by unilateral brain stem lesion."Movement Disorders. 16. 170-174 (2001)

[Publications] D.Muta,S.Goto et al.: "Bilateral pallidal stimulation for idiopathic segmental axial dystonia advanced from Meiqe syndrome..."Movement Disorders. (in press).

[Publications] S.Goto et al.: "Abolition of post-apoplectic hemichorea by Vo-complex thalamotomy : long-term follow-up study."Movement Disorders. (in press).

[Publications] T.Hamasaki,S.Goto et al.: "Early-generated preplate neurone in the developing telencephalon : Inward miqration into the striatum."Cerebral Cortex. (in press).

[Publications] T.Hamasaki,S.Goto, et al.: "A role of netrin-1 in the development of the subcortical structure striatum : Repulsive action"J.Neurosci.. (in press).

後藤恵熊本大学, 医学部・附属病院, 講師 (50240916)