2000 Fiscal Year Final Research Report Summary
ASSESSMENT OF CLINICAL APPLICATION OF ANESTHESIA DEPTH MONITOR EVALUATED BY SKIN VASOMOTOR REFLEX
| Project/Area Number |
10557140
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | KUMAMOTO UNIVERSITY |
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Principal Investigator |
SHIMODA Osamu Kumamoto university school of medicine, Department of anesthesiology, senior instructor, 医学部・附属病院, 講師 (40187480)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHITAKE Atsushi Kumamoto university school of medicine, Department of anesthesiology, stuff anesthesiologist, 医学部・附属病院, 助手 (80291540)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Sympathetic nerve / skin vasomotor reflex / assessment of anesthetic depth / nociception / evaluation of analgesic effects |
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| Research Abstract |
We performed clinical and animal studies to evaluate usefulness of the skin vasomotor reflex (SVmR) as anesthesia depth monitor. The summary of results is described below.
A.Clinical studies
1) Depth of anesthesia and the SVmR-amplitude indicate inverse proportion if intensity of stimuli was constant.
2) Intensity of stimuli and the SVmR-amplitude had proportional relationship if depth of anesthesia was constant.
3) Patients with diabetes and hypertension sometime indicated normal autonomic functions detected above-mentioned tests.
4) Above-mentioned relationships between the magnitude of the SVmR and intensity of stimuli (heat stimuli) was also observed in awake and slightly sedated volunteers with nitrous-oxide inhalation or midazolam i.v..
B.Animal (rat) study
1) Analyses of most reproductive and sensitive location suitable for measurement of the reflexous flow drop (RFD) with laser-Doppler flowmeter ; disclosed tail artery>basis of ear pinna artery>superficial planter.
2) A linear relationship between the magnitude of the RFD and intensity of stimuli (electrical stimuli) was also observed in rats. However correlation factor in rats was smaller than that in human. Further studies should be need for elucidating the mechanism of the SVmR and the RFD.
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