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2001 Fiscal Year Final Research Report Summary

Study on health

Research Project

Project/Area Number 10557200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 矯正・小児・社会系歯学
Research InstitutionNational Institute of Infections Diseases

Principal Investigator

HARADA Nobuhiro  National Institute of Infections Diseases, Dept. of Org. science, Director, 口腔科学部, 部長 (70180916)

Co-Investigator(Kenkyū-buntansha) INABA Daisuke  Iwate Medical University, Dept. of Preveertive Dentistry, Associate Professor, 歯学部, 助教授 (90146085)
YOSHIMITSU Masami  Iwate Medical University, Dept. of Preveertive Dentistry, Professor, 歯学部, 教授 (80092451)
ETO Akoko  National Institute of Infections Diseases, Dept. of Org. science, Researcher, 口腔科学部, 研究員 (50291125)
Project Period (FY) 1998 – 2001
Keywordselderly / dental caries / saliva / 唾液 / 連鎖球菌
Research Abstract

We investigated correlation between health status and health-promoting factors in the oral region. We assumed that health-promoting factors in the oral region would play an important role to prevent a man from infecting serious diseases through respiration and feeding. We performed oral examination of elderly people who keep their own teeth of 20 at the age of 80 (we call them 8020 people), according to WHO oral examination procedures. In detail, composition of oral bacterial flora, saliva constituent, saliva volume, salivary buffering were examined. Blood constituent, diet convention, athletic capacity were studied to clarify their relation with oral health status. Bacterial species studied were Candida albicans, Streptococcus mutans. Streptococcus sobrinus, Streptococcus pneumoniae, Psedomonos aeruginosa, Staphylococcus aureus. Haemophilias oarainfluenzae, etc. Furthermore, we put our attention on antibacterial peptide in saliva, such as defensin and histatin, and did quantitative analysis of these peptides.

  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Akifusa S.: "Increase in Bcl-2 level promoted by CD40 ligation correlates with inhibition of B cell apoptosis"Exp. Cell. Res.. 238. 82-89 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aizawa F.: "A survey of Potential risk factors for HIV transmission through denial practice in Japan"Asia Pac. J. Public Health. 10. 21-28 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toda A.: "Caries risk factors among three-year old children in Chiba, Japan"Asia Pac. J. Public Health. 11. 109-112 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato H: "The immunogenicity of various peptide antigens in ducing cross-reactiry antibodies"Oral Microbiol Immunol.. 14. 213-219 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] ETO A: "Inhibitory effect of a self-derived peptide on glucosytransferase of Streptococcus mutans"J. Biol. Chem.. 274. 15797-15802 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi H: "New dental drag delivery system for removing mutans streptococci from the oral cavity"Jpn J Infect. Dis. 53. 211-212 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki T.: "Role of FIFO-ATPase in the growth of streptococcus mutans GSS"J Appl. Microbiol.. 88. 555-562 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Harada N.: "Current understanding of the cause of dental caries"Jpn J. Infect Dis.. 53. 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matin K: "Effects of monoclonal antibodies in stoplococci mutans attachorenz"Jpn. Association for Bacterial Adherence Research. 14. 16-20 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Salam MA: "Isolation of oppotrunistic pathogens in dental plagne, saliva and tonsil samples from elderly"Jpn J. Infect Dis.. 54. 193-195 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Senpuku H.: "Inhibitory effects of Morbs against a surface protein antigen in real-time adherence 〜"Scard J Immunol.. 54. 109-116 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata T: "Periodontitis and serum interleukin-6 levels in the elderly"Jpn J. Infect Dis. 54. 69-71 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nomura Y.: "Mutans streptococci and lactobacillus as risk factors for dental caries in 12-year-old children"Jpn J. Infect Dis.. 54. 43-45 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi H: "Clinical study of mutans streptococci using 38S and monoclonal antibodies"Jpn J. Infect Dis.. 54. 34-36 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanada N: "Cloning and nucleotide sequence analysis of the streptococcus sabrinus gtf u gene"Biochem. Biophys. Acta. 20375. 1-5 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanada N: "The relationship between oral health status and biological and psychosocial function 〜"Archirey of Gerontology and Geriatrics. 33. 133-140 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada A: "The relation between tube feeding and Baudorcnes aeruginosa detection in the oral cavity"J Gerontal A Biol Sci Med Sci. 57. M71-M72 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akifusa S.: "Increase in Bcl-2 level promoted by CD40 ligation correlates with inhibition of B cell apoptosis induced by vacuolar type H(+)-ATPase inhibitor"Exp Cell Res. 238(1). 82-89 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aizawa F.: "A survey of potential risk factors for HIV transmission through dental practice in Japan"Asia Pac J Public Health. 10(1). 21-28 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada A.: "Caries risk factors among three-year old children in Chiba, Japan"Asia Pac J Public Health. 11(2). 109-112 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato H.: "The immunogenicity of various peptide antigens inducing cross-reacting antibodies to a cell surface protein antigen of Streptococcus mutans"Oral Microbiol Immunol. 14(4). 213-219 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eto A.: "Inhibitory effect of a self-derived peptide on glucosyltransferase of Streptococcus mutans. Possible novel anticaries measures"J Biol Chem. 274(22). 15797-15802 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi H.: "New dental drug delivery system for removing mutans streptococci from the oral cavity : effect on oral microbial flora"Jpn J Infect Dis. 53(5). 211-212 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki T.: "Role of F1FO-ATPase in the growth of Streptococcus mutans GS5"J Appl Microbiol. 88(4). 555-562 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanada N.: "Current understanding of the cause of dental caries"Jpn Infect Dis. 53(1) Review. 1-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matin, K.: "Effects of monoclonal antibodies in Streptococcus mutans attachment"Jpn. Association for Bacterial Adherece Reserch. 14. 16-20 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Salam MA,: "Isolation of opportunistic pathogens in dental plaque, saliva and tonsil samples from elderly"Jpn J Infect Dis. 54((5). 193-195 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Senpuku H.: "Inhibitory effects of MoAbs against a surface protein antigen in real-time adherence in vitro and recolonization in vivo of Streptococcus mutans"Scand J Immunol. 54(1-2). 109-116 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata T.: "Periodontitis and serum interleukin-6 levels in the elderly"Jpn J Infect Dis. 54(2). 69-71 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nomura Y.: "Mutans streptococci and Lactobacillus as risk factors for dental caries in 12-year-old children"Jpn J Infect Dis. 54(1). 43-45 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi H.: "Clinical study of mutans streptococci using 3DS and monoclonal antibodies"Jpn J Infect Dis. 54(1). 34-36 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanada N.: "Cloning and nucleotide sequence analysis of the Streptococcus sobrinus gtfU gene that produces a highly branched water-soluble glucan"Biochem. Biophys. Acta. 20375. 1-5 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanada N.: "The relationship between oral health status and biological and psychosocial function in the bedridden elderly"Archives of Gerontology and Geriatrics. 33. 133-140 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada A.: "The relation between tube feeding and Pseudomonas aeruginosa detection in the oral cavity"J Gerontol A Biol Sci Med Sci. 57(1). M71-M72 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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