1999 Fiscal Year Final Research Report Summary
Studies on Synthesis of Phospha-sugars by a New Route and Their Enzyme Inhibition
| Project/Area Number |
10640521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
HANAYA Tadashi Okayama Univ., Center of Instrumental Analysis, Assistant Professor, 機器分析センター, 助教授 (70189588)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hiroshi Okayama Univ., Faculty of Science, Professor, 理学部, 教授 (70032828)
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| Project Period (FY) |
1998 – 1999
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| Keywords | phospha-sugar / C-P bond / D-galactofuranose / D-mannosamine / vicinal coupling constant |
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| Research Abstract |
A New Route for Preparation of Pyranose-type Phospha-sugars.
D-gluco and L-idopyranose phospha-sugars were prepared in 6 steps, by starting with 3, 6-di-O-benzyl-1, 2-O-isopropylidene-α-D-xylo-hexofuranos-5-ulose.
2. Synthesis of D-Galactopyranose Phospha-sugar.
D-galactopyranose phospha-sugar was prepared in 6 steps, by starting with 3, 6-di-O-benzyl-1, 2-O-isopropylidene-β-L-arabino-hexofuranos-5-ulose.
3. Synthesis of D-mannosamine Phospha-sugar.
3, 6-Di-O-benzyl-5-O-deoxy-5-dimethylphosphinyl-1,2 O-isopropylidene-α-D-glucofuranose was converted, in 4 steps, into methyl 2-acetamido-3, 6-di-O-benzyl-2, 5-dimethoxyphosphinyl-α-D-mannofuranoside, which led to 3, 5-di-O-benzyl derivatives of D-mannosamine phospha-sugar.
4. The effect of a Phosphorus Atom upon Vicinal ィイD11ィエD1H-ィイD11ィエD1H Coupling Constants in Phospha-sugars.
Additivity constants for phosphorus were estimated for the prediction of vicinal ィイD11ィエD1H-ィイD11ィエD1H coupling constants by means of an additivity rule in a series of pyranose-type phospha-sugars.
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Research Products
(6 results)
