2000 Fiscal Year Final Research Report Summary
Effects of White Blood Cells on the Vasculare Resistance in Microvessels
| Project/Area Number |
10650189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Kansai University |
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Principal Investigator |
SUGIHARA-SEKI Masako Kansai University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (80150225)
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| Project Period (FY) |
1998 – 2000
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| Keywords | microvessels / white blood cells / red blood cells / vascular resistance / numerical simulation |
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| Research Abstract |
This project is aimed to study the effects of white blood cells on the vascular resistance in microvessels, from a fluid-dynamical point of view. Firstly, animal experiments were performed using an intravital microscopy to observe the behavior of white blood cells in microvessels of the mesentery of rats, under various circumstances. We observed accumulation of red blood cells behind a white blood cell in capillaries, due to the lower velocity of the white blood cell compared to the red blood cells, plugging of white blood cells at the entrance of capillaries, and rolling and adherence of white blood cells onto the endothelium of venules. To evaluate the effect of white blood cells on the microvascular resistance, we numerically analyzed the blood flow around white blood cells in microvessels. It was shown that accumulation of red blood cells behind a white blood cell in capillaries elevates the resistance of the capillary to a significant degree, in agreement with the whole organ perfusion experiments. Adhesion of white blood cells to the endothelium of venules was found to increase the microvascular resistance, depending on the number of cells, and vessel diameter. The increase is more significant for smaller venules
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