1999 Fiscal Year Final Research Report Summary
Studies on high-dimensional functions of glycoconjugates toward development of new medicines and biomaterials
| Project/Area Number |
10660107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | GIFU UNIVERSITY |
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Principal Investigator |
ISHIDA Hideharu Gifu University, Associated Professor, 農学部, 助教授 (20203002)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Autoimmune Disease / Neural injury / Auto antibody / Ganglioside / Guillain-Barre |
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| Research Abstract |
Certain species of anti-gangliosides are associated with specific clinical features in various neurologic diseases such as Guillain-Barre syndrome (GBS). In this project, two kinds of glyco-conjugates were synthesized to clarify the mechanism to cause GBS as well as the mechanism to produce autoantibodies to gangliosides. One is the minor ganglioside with the complex structure, GalNAc-GD1a, Lactoganglio-1 and Lactoganglio-2, which are found in nervous system. Another is Lipopolysaccharide (LPS) of Campylobacter jejuni (C.jejuni) which is known to infect the patients of GBS prior to appearance of GBS.All of the target molecules have been synthesized successfully in our hands, and the evaluation of the functions of these molecules are now under investigation.
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