1999 Fiscal Year Final Research Report Summary
c-Src Signaling that regulates Cell Adhesion
| Project/Area Number |
10670137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
HAMAGUCHI Michinari Nagoya University, School of Medicine, Professor, 医学部, 教授 (90135351)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Satoru School of Medicine, Assistant Prof., 医学部, 講師 (50242110)
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| Project Period (FY) |
1998 – 1999
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| Keywords | cadherin / Src kinase / signal transduction / cell adhesion / Ras / MAP kinase |
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| Research Abstract |
The aim of this study is to clarify the critical signaling pathway for the regulation of cell adhesion that depends on reversible biochemical reaction regulated by c-Src. Based on our previous report that Src kinase can regulate cell adhesion, we planned to clarify the regulation of cell adhesion dependent on cell cycle and NO-signaling.
In this study we found that Crk, an adopter molecule that binds c-Src to activate it, suppressed cadherin-dependent cell adhesion via Ras-MEK pathway. In addition we found NO produced by e-NOS could directly activate c-Src kinase.
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