2001 Fiscal Year Final Research Report Summary
The role of glycoxidative low-density lipoprotein. A novel modified low-density lipoprotein, in the formation of atherosccleotic lesions.
| Project/Area Number |
10670183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAKATA Noriyuki School of Medicine, Professor, 医学部, 教授 (20134273)
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| Co-Investigator(Kenkyū-buntansha) |
MENG Jing School of Medicine, Assistant Professor, 医学部, 助教授 (50299567)
MATSUNAGA Akira School of Medicine, Assistant Professor, 医学部, 助教授 (60221587)
TASHIRO Tadashi School of Medicine, Assistant Professor, 医学部, 助教授 (20268981)
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| Project Period (FY) |
1998 – 2001
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| Keywords | Serum abumin / Low-density Lipoprotein / Glycoxidation / Antioxidant activity / Lipid peroxidation / Oxidation / Carboxymethyllysine / Malondialdehyde |
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| Research Abstract |
N^ε-(carboxymethyl)lysine was formed in glycoxidative human serum albumin (HSA), butnot in oxidative HSA.
Glycoxidation and oxidation of HSA significantly decreased the contents of free thiol groups.
The antioxidant activity of glycoxidative HSA to LDL-oxidation was the lowest among various modified HSAS.
Oxidative HSA showed a moderate decrease in antioxidant activity.
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