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1999 Fiscal Year Final Research Report Summary

A Study on Relationships between Sudden Death and Data from Periodic Health Examination in Workers

Research Project

Project/Area Number 10670364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionTeikyo University

Principal Investigator

MURATA Katsuyuki  Teikyo University School of Medicine, Department of Hygiene & Public Health, Associate Professor, 医学部, 助教授 (80157776)

Co-Investigator(Kenkyū-buntansha) YANO Eiji  Teikyou University School of Medicine, Department of Hygiene & Public Health, Professor, 医学部, 教授 (50114690)
Project Period (FY) 1998 – 1999
KeywordsSudden Death / Periodic Health Examination / Electrocardiogram (ECG) / Day Workers / Shift Workers / Heart Rate Variability / Cardiovascular Disease / Heart-Rate Corrected QT interval (QTc)
Research Abstract

Since a topic on the "sudden death" was limelighted in Japanese workers, more than ten years have passed. Although myocardial infarction due to overwork has been suggested to be a main causal disease of sudden death, the causation between them remains unclear. At least, periodic health examination, carried out in the workplace every year, seems to have little value for the prediction of such a death/disease. For this reason, the significance of ten items of the periodic health examination stipulated in the Industrial Safety and Health Act (44 sections), I.e., blood pressure, urinalysis, anemia, liver function, lipid, electrocardiogram (ECG), etc., is impeached.
The main results of this research are as follows: (1) The ECG data were compared between workers who died suddenly and healthy workers, but no significant difference in the abnormal waveforms was found between them. The ECG data obtained at the time of the periodic health examination did not appear to be effective for the predict … More ion of sudden death. (2) What was the most effective for the prediction of sudden death was viewed by using the past references. Some papers have reported that the heart-rate corrected QT interval (QTc) of ECG and heart rate variability are very useful for the prognosis of patients with myocardial infarction and diabetes mellitus. (3) The most reasonable estimate of the relative risk for cardiovascular diseases induced by shift work has been suggested to be around 1.4. To determine whether shift work affects the QTc and blood pressure of workers without overt cardiovascular dysfunction, shift workers and day workers who underwent an ECG examination and blood pressure measurements in 1986 were followed for 10 years. The shift workers had a significantly longer QTc than the day workers, and the adjusted odds ratio of shift work to the prolonged QTc (440 msecィイD11/2ィエD1) was 8.15 (90% confidence interval, 1.31-50.5). These findings suggest that the increased risk for cardiovascular mortality in shift workers may be attributable to prolongation of the QTc. Less

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Murata K, yano E, Shinozaki T: "Impact of shift work on cardiovascular functions in a 10 year follow-up study"Scandinavian journal of Work, Environment, and Health. 25. 272-277 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata K, Yano E, Shinozaki T: "Cardiovascular dysfunction due to shift work"Journal of Occupational and Environmental Medicine. 41. 748-753 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村田勝敬: "環境・産業衛生領域の有害因子による自律神経影響の評価-心拍変動の測定"日本衛生学雑誌. 54. 516-525 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata K, Yano E, Shinozaki T.: "Impact of shift work on cardiovascular functions in a 10-year follow-up study"Scandinavian Journal of Work, Environment, and Health. 25. 272-277 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata K, Yano E, Shinozaki T.: "Cardiovascular dysfunction due to shift work"Journal of Occupational and Environmental Medicine. 41. 748-753 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata K.: "Assessment of autonomic neurotoxicity of environmental and occupational factors as determined by heart rate variability: recent findings"Japanese Journal of Hygiene. 54. 516-525 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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