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1999 Fiscal Year Final Research Report Summary

PR-39 gene transduction suppresses heaptocellular carcinoma cell metastasis by inhibition of signal transduction

Research Project

Project/Area Number 10670444
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionASAHIKAWA MEDICAL COLLEGE

Principal Investigator

FUJIMOTO Yoshinori  Asahikawa Medical College, Medicine Instructor, 医学部, 助手 (90292127)

Co-Investigator(Kenkyū-buntansha) KOHGO Yutaka  Asahikawa Medical College, Medicine Professor, 医学部, 教授 (10133183)
Project Period (FY) 1998 – 1999
Keywordsantimicrobial peptide / PR-39 / syndecan / actin / signal transduction / hepatocellular carcinoma / MAP kinase
Research Abstract

PR-39 is an endogenous proline-rich antimicrobial peptide which induces the synthesis of syndecan-1, a transmembrane heparan sulfate proteoglycan involved in cell-to-matrix interactions and wound healing. Previously, we revealed that PR-39 has functions involved in the suppression of motile activity and alteration of actin structure on human hepatocellular carcinoma cells in addition to the suppression of invasive activity which might result from the induction of syndecan-1 expression. To clarify this mechanism we transfected PR-39 gene into NIH3T3 cells transformed with activated k-ras gene. The PR-39 gene transfectant revealed changes of morphology, actin structure, proliferation rate and MAPK activity. PR-39 might affect ras signal transduction.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Ohtake T,Fujimoto Y,Ikuta K,Saito H,Ohhira M,Ono M,Kohgo Y.: "Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells"Brit J Cancer. 81. 393-403 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤本佳範,大竹孝明,鈴木康秋,田中浩二,生田克哉,斉藤浩之,大平基之,小野稔,高後裕: "Protineに富む内因性抗菌ペプチドPR-39遺伝子を用いたシグナル伝達ブロックによる肝癌転移の遺伝子治療"日本癌病態治療研究会誌. 5. 176-177 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高後裕,藤本佳範,浦等: "増殖因子受容体からのシグナル伝達経路の阻害によるがん治療法の開発"がん治療のあゆみ. 18. 13-18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohtake T, Fujimoto Y, Ikuta K, Saito H, Ohhira M, Ono M, Kohgo Y.: "Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cell."Brit J Cancer. (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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