1999 Fiscal Year Final Research Report Summary
The effect of anti-ganglioside antibodies on ion channels
| Project/Area Number |
10670595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kagoshima University |
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Principal Investigator |
HIGUCHI Itsuro University Hospital, Faculty of Medicine, Kagoshima University, Assistant Professor, 医学部・附属病院, 講師 (80183573)
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| Co-Investigator(Kenkyū-buntansha) |
UMEHARA Fujio Faculty of Medicine, Kagoshima University, Assistant Professor, 医学部・附属病院, 講師 (20271140)
KAMEYAMA Masaki Faculty of Medicine, Kagoshima University, Professor, 医学部, 教授 (60150059)
ARIMURA Kimiyoshi Faculty of Medicine, Kagoshima University, Associate Professor, 医学部, 助教授 (20159510)
KASUNOKI Susumu Tokyo University, University Hospital, Research Associate, 医学部・附属病院, 助手 (90195438)
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| Project Period (FY) |
1999 – 2000
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| Keywords | conduction block / ion channel / Anti-ganglioside antibody / CIDP / whole-cell clamp / Guillain Barre syndrome |
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| Research Abstract |
Anti-ganglioside antibodies are often detected in the sera of patients with Guillain-Barre syndrome(GBS) and multifocal motor neuropathy with persistent conduction block(MMN) and chronic inflammatory demyelinating polyradiculoneuropathy(CIDP). The physiological role of anti-ganglioside antibodies is debated. In this study, we tested the effect of immunoglobulins from patients with anti-ganglioside antibodies on ion currents using the whole-cell clamp method. NaィイD1+ィエD1 currents were not affected in both chronic and direct conditions. The suppression of NaィイD1+ィエD1, which has been proposed as the pathomechanism of conduction block, may be due to secondary effects of immunoglobulin on axonal membrane.
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