1999 Fiscal Year Final Research Report Summary
Mechanisms of the hypertrophy/hyperplasia of heart/vessels and the cardio-reno-protection to ischemia
| Project/Area Number |
10670627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
KOHZUKI Masahiro University Hospital, Lecturer, 医学部・附属病院, 講師 (70234698)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIMOTO Masahiro University Hospital, Research Associate, 医学部・附属病院, 助手 (00271924)
SOMA Jun University Hospital, Lecturer, 医学部・附属病院, 講師 (50301049)
YOSHIDA Kazunori Graduate School of Medicine, Tohoku University, Research Associate, 大学院・医学系研究科, 助手 (90292218)
ONODERA Hiroshi Graduate School of Medicine, Tohoku University, Associate Professor, 大学院・医学系研究科, j助教授 (20214207)
SATO Tokutaro Graduate School of Medicine, Tohoku University, Professor, 大学院・医学系研究科, 教授 (70004687)
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| Project Period (FY) |
1998 – 1999
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| Keywords | chemokine / Wistar-Kyoto rat / SHR / ischemia / reperfusion / heart |
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| Research Abstract |
1. We assessed the renal benefits of cicletanine (CIC), a furopyridine derivative drug with diuretic and antihypertensive properties, in diabetic spontaneously hypertensive Izmo rats (SHR) and Wistar-Kyoto rats (WKY) with renal impairment. CIC has a renal-protective action, which is not related to improvement of diabetes and improvement of high blood pressure in diabetic WKY and diabetic SHR. The actions might be due to the reduction of intraglomerular capillary pressure or protection of the renal glomerular vascular endothelial cell / mesangial cell injury through stimulation of PGI2 generation or elimination of free radicals, although the mechanism remains to be further investigated.
2. Usefulness of the systemic hypertension induced by transient angiotensin II infusion in tumor therapy was established. The mechanism of the increased blood flow in tumor vessels is the decreased numbers of angiotensin II type A receptor in rat LY-80 and AH109A tumor and human gastric cancer which revea
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led by quantitative n vitro autoradiography.
3. We assessed the renal effects of mild to severe chronic treadmill exercise in the spontaneously hypertensive rats (SHR) remnant kidney model of chronic renal failure (CRF). Chronic treadmill exercise significantly attenuated the increase in proteinuria and in serum total cholesterol levels intensity-dependently. Moderate-Ex significantly and effectively protected against increases in the percentage of focal glomerular sclerosis (FGS). Enalapril, losartan and amlodipine significantly decreased blood pressure, further decreased proteinuria and the percentage of FGS similarly in the rats with moderate Ex. These results indicate that exercise does not worsen renal function and suggest that exercise have renal-protective actions in this model of rats. Moreover the antihypertensive therapy has synergic renal-protective effects in this model of rats.
4. Effects of intense exercise on renal oxygen consumption and urinary sodium excretion were assesses. Less
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