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2001 Fiscal Year Final Research Report Summary

Clinical efficacy of brain blood flow SPECT in the diagnosis of pochiatric disorders in the aged

Research Project

Project/Area Number 10670869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSaitama Medical School

Principal Investigator

MACHIDA Kikuo  Saitama Medical School, Professor, 医学部, 教授 (40010235)

Co-Investigator(Kenkyū-buntansha) HOSONO Makoto  Saitama Medical School, lecturer, 医学部, 講師 (00281303)
Project Period (FY) 1998 – 2001
Keywordsefficacy / Tc-99m-ECD / Tc-99m-HMPAO / I-123-IMP / alzheimer / Cerebral infarction / Pick / Multi-center study
Research Abstract

Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality enabling differential diagnosis of dementia. The purpose was to measure inter-obserYer variations in diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 of Alzheimer s Disease (AD) eight of multi-infarct dementia (MID), three of Pick's disease, five of other dementias and 22 normal controls, were interpreted by ten nuclear medicine physicians of variable experience before and after the addition of MRl. The physicians independently rated diagnoses that were listed beforehand according to a 5-point scale with clinical information provided. Recejyer-operating characteristics (ROC) curves and the area under the ROC curves (Az) was calculated. Az varied from 0. 48 to O. 87. Mean Az's were significantly larger (p < 0.05) before the addition of MRI than after the addition (0. 715 and 0. 629 for dementia vs, normal, O. 670 and O. 560 for AD or MID vs. normal, O. 610 and O. 416 for AD vs. normal, and O, 669 and O. 443 for AD vs. MID, respectively). Considerable inter-observer variation is present in BP-SPECT interpretation. The addition of MRI lowered the diagnostic usefulness in this study. BP-SPECT may be effective for the evaluation of dementia independent of MRI for nuclear medicine physicians

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Machida K, Honda N et al.: "Measurement of decreased cerebellar blood flow of Machado-Joseph disease by brain perfusion SPFCT"Jap. J. Tomogr. 28. 94-98 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosono M, Machida K et al.: "Oligodendroglioma with cystic componentin infant"Computerized Medical Imagining and Graphics. 25. 361-365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosono MN et al.: "Rhenium-188-labeled anti-neural cell adhesion molecule antibodies with 2-iminothiolane modification for targeting small-cell lung cancer"Annals of Nucleon Medicine. 14. 173-179 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosono M et al.: "Two-step targeting and dosimetry for small cell lung cancer xenograft with anti-NCAM/antihistamine…"J Nucl Med. 40. 1216-1221 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosono MN et al.: "Localization of colorectal carcinoma by rhenium-188-labeled B72.3 antibody in xenograft mice"Annals Nuclear Medicine. 12. 83-88 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 町田喜久雄他: "脳MRIの意義と正常解剖"Medical Practice. 16. 869-877 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 町田喜久雄編: "明日の核医学のために(第37回日本核医学記念)"日本アクセル・シュプリンガー出版. 275 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Machida K et al: "Measurement of decreased cerebellar blood flow of Machidao-Joseph disease by brain perfusion SPECT"Japanese J Tomogr. 28(2). 94-98 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosono M, Machida K et al: "Oligodendroglioma with cystic component in infant"Computerized Medical Imaging and Graphics. 25. 361-365 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosono MN et al: "Rhenium 188-labeled anti-neural cell adhesion molecule anti-bodies with 2-iminothiolane for targetting small cell lung cancer"Annals of Nuclear Medicine. 14(3). 173-179 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosono M et al: "Two-step targetting and dosimetry for small cell lung cancer xenograft with anti-NCM/antihistamine bispecific antibody and radioiodinated bivalent hapten"J Nucl Med. 40(7). 1216-1221 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Machida K et al: "Brain MRI : Brain tumor"Medical Practice. 16(6). 1044-1051 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Machida K et al: "Brain MRI : Brain tumor"Medical Practice. 16(7). 1204-1211 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Machida K, editor: "Nuclear Medicine, Tomorrow, in memory of 37 th Congress of Japanese Society of Nuclear Medicine"Axel Springer Japan Publishing, Tokyo. 1-275 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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