2000 Fiscal Year Final Research Report Summary

Molecular gene ticresearch on the relationship between personality traits and polymorphisms

Research Project

Project/Area Number	10670892
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	Yamanashi Medical University
Principal Investigator	SHIOE Kunihiko Yamanashi Medical University, Faculty of Medicine, assistant Professor, 医学部, 講師 (90215939)
Co-Investigator(Kenkyū-buntansha)	HIRANO Masami Yamanashi Medical University, Faculty of Medicine, assistant Professor, 医学部, 講師 (80228808)
Project Period (FY)	1998 – 2000
Keywords	dimensional classification of personality / behavioral genetics / polymorphism / serotonin transporter / dopamine receptor / mood disorder / ドーパミン受容体 / 病前性格
Research Abstract	We conducted visual investigations. On the D4DR gene, we classified homozygotes with 4 repeats/4 repeats as the M group, heterozygotes with 4 repeats/less than 4 repeats as the S group, and 4 repeats/more than 4 repeats as the L group. Next, we examined scores for distribution of TCI (NS, HA, RD, PS), and compared TCI.scores among the three groups. All 4 matrices were examined, but significant relationships were observed only between D4DR polymorphism and RD scores. Afterwards, , we have penformed an association study of polymorphisms related to the promorter region of the serotonin transporter gene between patients with mood disorders and healthy subjects. Short allele frequency of bipolar patients was higher than controls.

(5 results)