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2001 Fiscal Year Final Research Report Summary

Possible relationship between polyamines and traumatic stress: Changes in polyamine levels after weter-immesdion restraint stress in mouse brain

Research Project

Project/Area Number 10670903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNotre Dame Seishin University (2001)
Naruto University of Education (1998-2000)

Principal Investigator

HAVASHI Yasushi  HEADINVESTIGATER, 人間生活学部, 教授 (80173037)

Co-Investigator(Kenkyū-buntansha) TANAKA Junichi  Naruto University of Education Faculty of School Education Department of Human Development Associate Professor, 学校教育学部, 助教授 (00212035)
Project Period (FY) 1998 – 2001
Keywordsstress / polyamines / putrescine / spermidine / spermine / brain / plasma / mouse
Research Abstract

Previous studies, by others and by us, have shown that neuronal stress and injury in the epileptic brain significantly alter polyamine metabolism, resulting in a marked elevation of the putrescine level. Recently, it was also reported that brain polyamine metabolism is modified by traumatic stress and may be involved in affective disorders. In this study, we measured the polyamine levels in the frontal cortex, hippocampus, hypothalamus, and plasma after applying water-immersion restraint stress, to further clarify the relationship between polyamines and traumatic stress. To stress mice, they were confined in a restraint stress-cage and immersed in water maintained at 25℃ for 2h. The animals were decapitated 5min, 6h, 24h and 48h after the cessation of stress. In all parts of the brain, the putrescine levels were significantly elevated 24h after stress application. The spermidine and spermine levels were unchanged or slightly reduced in the frontal cortex and hypothalamus 6h and 24h after stress application. In the plasma, there is no change in polyamine levels at any time intervals after stress application. In the case of restraint stress without water-immersion, putrescine level was increased only in the frontal cortex. Pretreatment with diazepam (5mg/kg, i. p.) reduced the stress-induced polyamine changes. These results indicate that the change of polyamine metabolism is linked to traumatic stress and its magnitude appears to be related to the intensity of the stressor.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yasushi Hayashi, et al.: "Pentylenetetrazol-induced kindling stimulates the polyamine interconversion pathway in rat brain"Brain Research. 828. 184-188 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasushi Hayashi, et al.: "Involvement of the polyamine interconversion pathway in the regulation of putrescine level and brain excitability in pentylenetetrazol-induced kindling"Journal of Brain Science. 25. 109-114 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasushi, Hayashi.: "Pentyleneterazol-induced kindling stimulates the polyamine interconversion pathway in rat brain"Brain Research. 828. 184-188 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasushi, Hayashi.: "Involvement of the polyamine interconversion pathway in the regulation of putrescine level and brain excitability in pentylenetetrazol-induced kindling"Journal of Brain Science. 25. 109-114 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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