1999 Fiscal Year Final Research Report Summary
Viral infections as a risk factor of psychiatric diseases
| Project/Area Number |
10670906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagasaki University |
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Principal Investigator |
HYASHIDA Masaki Nagasaki Univ., Health Center, Asst. Prof., 保健管理センター, 講師 (70264223)
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Yuji Mie Univ., Dep. of Medicine, Prof., 医学部, 教授 (40010318)
YOSHITAKE Kazuyasu Nagasaki Univ., School of Med., Asst. Prof., 医学部, 講師 (40281208)
TSUJITA Takahiro Nagasaki Univ., Univ. Hosp. Attached School of Med., Asst. Prof., 医学部・付属病院, 講師 (40304919)
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| Project Period (FY) |
1998 – 1999
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| Keywords | viral infection / monozygotic twins / schizophrenia / Borna disease virus / pestivirus |
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| Research Abstract |
This study was designed to investigate the influence of the past viral infections (Borna disease virus or pestivirus infection) on the risk of suffering from schizophrenia. We tried to detect antibody against Borna disease virus (BDV) in the sera and BDV RNA or pestivirus RNA in the peripheral bloods from 31 schizophrenic patients (included 3 pairs of monozygotic twins discordant for schizophrenia) and 55 healthy volunteers, who gave informed consent. BDV RNA and pestivirus RNA were detected from 3 and 1 of them, respectively. Neither of these viral RNAs was found in monozygotic twins. Anti-BDV antibody was detected from none of all participants. It is necessary to investigate past viral infection of further more monozygotic twins discordant for schizophrenia.
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Research Products
(2 results)
