A study on association between SCA1 gene polymorphism and schizophrenia

1999 Fiscal Year Final Research Report Summary

• Project/Area Number: 10670909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of the Ryukyus
• Principal Investigator: HIGA Tsukasa University Hospital, University of the Ryukyus, Instructor, 医学部・附属病院, 助手 (90284984)
• Co-Investigator(Kenkyū-buntansha): NAGAMINE Masaru Genetic research center, University of the Ryukyus, Assistant Professor, 遺伝子実験施設, 助教授 (20189161)
• Project Period (FY): 1998 – 1999
• Keywords: An association study / Schizophrenia / Chromozome 6p / Spinocerebellar ataxia type 1 / Genetics

Research Abstract

The gene for spinocerebellar ataxia type 1 (SCA1) is a potential candidate gene for schizophrenia because of previous positive linkage findings in this resion (6p22-24), and the reported correlation between SCA1 onset and the number of CAG repeats suggesting anticipation. To evaluate whether the SCA1 gene might be involved in susceptibility to schizophrenia, we examined the amino-acid variant (S186C) of 83 Okinawan patients with schizophrenia and 104 Okinawan controls. This amino-acid change was not found in all of schizophrenia patients and controls. This result indicates that the amino-acid variant (S186C) is not relevant to schizophrenia.