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2000 Fiscal Year Final Research Report Summary

NK CELL ACTIVITY REGARDING DELIRIUM

Research Project

Project/Area Number 10670925
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Occupational and Environmental Health(UOEH)

Principal Investigator

NAKAMURA Jun  Dept.of Psychiatry, School of Medicine, UOEH, Professor, 医学部, 教授 (40148804)

Co-Investigator(Kenkyū-buntansha) OHMORI Osamu  Dept.of Psychiatry, School of Medicine, UOEH, Assistant Professor, 医学部, 講師 (70248558)
YOSHIMURA Reiji  Dept.of Psychiatry, School of Medicine, UOEH, Assistant Professor, 医学部, 講師 (90248568)
TERAO Takeshi  Dept.of Psychiatry, School of Medicine, UOEH, Associate Professor, 医学部, 助教授 (80217413)
Project Period (FY) 1998 – 2000
Keywordsdelirium / 3-methoxy-4-hydroxyphenylglycol(MHPG) / Natural killer(NK)cell activity / Prospective study
Research Abstract

We measured and comparaed levels of plasma free 3-methoxy-4-hydroxy-phenyl-(ethylene)glycol(pMHPG), a major metabolite of noradrenaline, and natural killer(NK)cell activity in 26 patients prior to undergoing operations for cardiovascular diseases 11 of whom expressed delirium and 15 of which did not. In conclusion, we found that pMHPG levels before the operations were higher in patients with post-operative delirium than in the patients without, while NK cell activity showed no difference between the two groups. It is possible that hyperactivity of noradrenargic neurons is connected with the development of post-operative delirium. Further, we considered that measurements of pMHPG level before operation might be a useful tool to predict the occurrence of post-operative delirium.

  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 中村 純: "せん妄の診断と評価"臨床精神薬理. 1. 1243-1249 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada,S.: "Saliva level of 3-methoxy-4-hydroxyphenylglycal in psychiatric outpatients with anxiety"International Clinical Psychopharmacology. 13. 213-217 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimura,R.: "Effects of risperidene on plasma free 3-methoxy-4-hydroxyphenylglycal(pMHPG)levels in pshizcphrenie patients"International Clinical Psychopharmacology. 15. 175-180 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,H.: "Visual perseveration : a new side effect of maprotiline"Acta Psychiatrica Scandinavia. 10. 476-477 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimura,R.: "Changes in plasma monoamine metabolites during acute lithium intoxication"Human Psychopharmacology-Clinical and Experimental. 15. 347-349 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueda,N.: "Delirious episodes induced by intravenous administration of clomipramine associated with an acute increase in its plasma concentrations."Psychiatry and Clinical Neuroscience. 54. 669-672 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村 純: "精神医学レビューNo.26 せん妄"ライフ・サイエンス. 8 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村 純: "総合病院精神医学マニュアル"医学書院. 5 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura, J., Ueda, N.: "Diagnosis and evaluation of delirium.(in Japanese)"Japanese Journal of Clinical Psychopharmacology. 1. 1243-1249 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada S.Yajima J.Harano M.Miki K.Nakamura J.Tsuda, A.. Shoji H.. Maeda, H., Tanaka M.: "Saliva level of 3-methoxdy-4-hydroxyphenylglycol in psychiatric outpatients with anxiety."International Clinical Psychopharmacology. 13. 213-217 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terao, T., Ohmori, O., Shinkai, T.: "A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration"Acta Psychiatrica Scandinavia. 99(5). 388-392 (1999)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, N., Nakamura, J.: "Delirium associated with physical disorder in dialysiss patients.(in Japanese)"Clinical dialysis. 15(9). 1269-1278 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura, J., Uchimura, N., Oshima, H., Motohka, H., Kotorii, N.: "Functional imaging analysis in alcoholics.(in Japanese)"Japanese Journal of Psychiatric Research on Alcohol. 6(2). 79-85 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshimura, R., Nakamura, J., Ueda, N., Terao, T.: "Effect of risperidone on plasma free 3-methoxy-4-hydroxyphenylglycol(pMHPG)levels in schizophrenic patients : relationship among plasma concentrations of risperidone and 9-hydroxyrisperidone"pMHPG levels, and clinical improvement International Clinical Psychopharmacology. 15(3). 175-180 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori, H., Terao, T., Nakamura, J.: "Visual preseveration : a new side effect of maprotiline."Acta Psychiatrica Scandinavia. 101(6). 476-477 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuno, T., Nakamura, J.: "Delirium(in Japanese)"CURRENTT THERAPY. 18(7). 1211-1216 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukimasa, T., Nakamura, J.: "Medication of insomnia and delirium in psycho-oncology.(in Japanese)"Japanese Journal of Clinical Psychopharmacology. 3(7). 635-641 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada, Y., Ueda, N., Yoshimura, R., Nakamura J.: "Effects of acute lithium intoxication on plasma monoamine metabolites.(in Japanese)"Japanese Journal of Clinical Psychopharmacology. 3(12). 1355-1359 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshimura, R., Yamada, Y., Ueda, N., Nakamura, J.: "Changes in plasma monoamine metabolites during acute lithium intoxication."Human Psychopharmacology-Clinical and Experimental-. 15(5). 347-349 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueda, N., Yoshimura, R., Etoh, S., Terao, T., Nakamura, J.: "Delirious episodes induced by intravenous administration of clomipramine associated with an acute increase in its plasma concentrations."Psychiatry and Clinical Neuroscience. 54(6). 669-672 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura, J., Yoshimura, R., Okuno, T., Ueda, N., Hachida, M., Yasumoto, K., Egami, H., Maeda, H., Nishi, M., Aoyagi, S.: "Association of plasma free-3-methoxy-4-hydoroxy-phenyl(ethylene)glycol, natural killer cell activity, and delirium in post-operative patients."International Clinical Psychopharmacology in preparation. (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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