2000 Fiscal Year Final Research Report Summary
The role of nm23 as a prognostic factor of leukemia
| Project/Area Number |
10670978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Saitama Cancer Center |
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Principal Investigator |
OKABE-KADO Junko SAITAMA CANCER CENTER, RESEARCH INSTITUTE, CHIEF RESEARCHER, 研究所, 主任研究員 (30161136)
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| Project Period (FY) |
1998 – 2000
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| Keywords | NM23 / PROGNOSTIC FACTOR / AML / LYMPHOMA / ELISA / SERUM / ELISA法 |
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| Research Abstract |
Expression levels of nm23-H1 and nm23-H2 mRNA in acute myeloid leukemia (AML) samples were significantly higher than that in normal blood cells, and a higher level of nm23-H1 expression was correlated with a poor prognosis in AML.To apply the prognosis based on the overexpression for other tumors, we made a detection system, sandwich ELISA for serum NM23-H1 protein. Using this system, we measured many hematological malignacies and malignant lymphoma. We showed the levels of serum NM23-H1 proteins of various hematological malignancies and the important function of serum NM23-H1 protein as a prognostic factor for AML and malignant lymphoma, especially aggressive non-Hodgkin's lymphoma.
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Research Products
(14 results)
