1999 Fiscal Year Final Research Report Summary
ROLE OF TG RICH RIPOPROTEINS IN ATHEROSCLEROSIS
| Project/Area Number |
10671059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | TOKYO MEDICAL AND DENTAL UNIVERSITY |
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Principal Investigator |
TANAKA Akira TOKYO MEDICAL AND SCHOOL OF MEDICINE, LECTURER DENTALUNIVERSITY, 医学部, 講師 (70171733)
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| Co-Investigator(Kenkyū-buntansha) |
MICHIRO Tamura TOKYO MEDICAL AND SCHOOL OF MEDICINE, ASSISTANTPROF.DENTALUNIVERSITY, 医学部, 助手 (10301152)
YASUSHI Kobayashi TOKYO MEDICAL AND SCHOOL OF MEDICINE, ASSISTANTPROF.DENTALUNIVERSITY, 医学部, 助手 (70225548)
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| Project Period (FY) |
1998 – 1999
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| Keywords | ApoB 48 receptor / Macrophage / Atherosclerosis / TG rich lipoprotein / Immunohistochemical stain / Reticuloendothelial System / Remnant / Carotid |
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| Research Abstract |
Unique receptor, apo B48 receptor, was identified in human monocytemacrophages. The receptor binds and internizes chylomoicrons, triglyceride (TG) rich VLDL, and VLDL devoid of apo E, but not acetyl LDL, via a domain in apo B48. The apo B48 receptor differs from the scavenger receptor family and LDL receptor family because it does not bind acetyl LDL and it binds VLDL devoid of apo E by an apo E-independent mechanism Immunohistochemical studies indicate colocalization of anti-apo B48 receptor Ab and monocyte-macrophage specific Ab in human atherosclerotic lesion foam cells. This suggests that apo B48 receptor may contribute to foam cell formation and atherosclerosis in abnormal state with elevated TG-rich lipoproteins.
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