| Research Abstract |
Genetic alterations in colorectal cancer and dysplasia (DS) in patients with ulcerative colitis (UC) were examined. Losses of heterozygosity (LOH) in chromosome 5q, 17p, 8p, 18q, 22p and microsatellite instability (MSI) were examined. LOH was observed in 36%(4/11)(5q), 67%(8/12)(17p), 59%(10/17)(8p), 0%(0/3)(18q) and 0%(0/3)(22p), which indicated the importance of the p53 gene in the development of colorectal tumors in UC. No lesions showed MSI. In an immunohistochemical analysis, the over expression of p53 was observed in 89% of invasive cancers, 70% of high-grade dysplasia, 57% of low-grade dysplasia and 0% of adenoma. This showed the effectiveness of immunohistochemical analysis for different diagnosis of adenoma and dysplasia in a clinical setting.
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