1999 Fiscal Year Final Research Report Summary
Development of a protein kinase-targeted immunoconjugates for the treatment of gastric cancer with peritonitis carcinomatosis
| Project/Area Number |
10671210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KITAMURA Kazuya Kyoto Prefectural University of Medicine, Digestive surgery, Assistant, 医学部, 助手 (10224966)
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| Project Period (FY) |
1998 – 1999
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| Keywords | gastric cancer / peritonitis carcinomatosis / monoclonal antibody / genistein |
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| Research Abstract |
A human-mouse chimeric monoclonal antibody was conjugated chemically with genistein. The conjugates (ch-A7-Gen) was produced with a 1 : 2 molar ratio of antibody to genistein. The conjugate showed a sufficient antigen binding activity and antigen-specific cytotoxicity. The cytotoxic activity was due to inhibition effect of protein kinase activity and apoptosis. Ch-A7-gen markedly suppressed tumor growth in nude mice with human gastric cancer xenograft, whereas the tumoricidal effect of the control conjugate was not prominent. This result indicates that a ch-A7-gen is a promising tool for the treatment of patients with gastric cancer with peritonitis carcinomatosis.
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[Publications] Okamoto K, Sawai K, Minato H, Yada H, Shirasu M, Sakakura C, Otsuji E, Kitamura K, Taniguchi H, Hagiwara A, Yamaguchi T, Takahashi T: "Number and anatomical extent of lymph node metastases in gastric cancer : Analysis using intra-lymph node injection of activated carbon particles(CH40)"Jnp J Clin Oncol. 29. 74-77 (1999)
Description
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