1999 Fiscal Year Annual Research Report

肝細胞癌多中心性発生の病理学的ならびに分子生物学的診断とその治療成績

Research Project

Project/Area Number	10671211
Research Institution	Osaka City University Medical School
Principal Investigator	木下博明大阪市立大学, 医学部, 教授 (50047122)
Co-Investigator(Kenkyū-buntansha)	久保正二大阪市立大学, 医学部, 講師 (80221224)
Keywords	肝細胞癌 / 多中心性発癌 / 肝内転移 / C型肝炎 / B型肝炎
Research Abstract	肝切除施行肝細胞癌(肝癌)症例の多中心性発癌を病理診断法,すなわち(1)一方の肝癌が高分化型肝癌組織のみから構成される場合,(2)いずれの肝癌においても中あるいは低分化肝癌組織の周囲に高分化型肝癌組織がみられる場合との定義にしたがって検索し,そのリスク因子と臨床的意義について検討した.その結果,輸血歴を有する症例,高ICG15分値,ALT高値,高ビリルビン血症,さらにHCV感染およびHBV感染既往あるいはHCV単独感染が有意な因子であった.また非癌部肝組織の肝炎活動性や線維化の程度が高くなるほど多中心性発癌のリスクは増大した.さらに女性においてはX染色体上のVariable Number of Tandem Repeat領域を有するAndrogen Receptor Geneのメチル化パターンより多中心性発癌巣か転移巣かの鑑別が可能であることが示唆された. またそれらの肝切除後成績は多中心性発癌症例と単発例に有意差はみられなかったが,肝内転移症例の術後成績は多中心性発癌症例に比較し,有意に低値であった.したがって多発肝癌症例においてそれらが多中心性発癌か,肝内転移かを鑑別することは臨床的に意義あるものと考えられた.さらに肝切除後の多中心性発癌のリスク因子は低血小板数などであった.これらより多中心性発癌のリスクから発癌ポテンシャルを類推し,それらを踏まえた肝癌に対する治療法や術式の選択が重要であると考えられた.

Research Products
(11 results)

All Other

All Publications (11 results)

[Publications] Kubo, S, et al: "Effects of continuous hepatitis with persistent hepatitis C viremia on outcome after resection of hepatocellular carcinoma"Jpn J Camaer Res. 90. 162-170 (1999)
[Publications] Tanaka H, et al: "Influence of histological inflammatory activity on regenerative capacity of liver after percutaneons troms hepatic portal vein embolization"J. Gastroentaol.. 34. 100-104 (1999)
[Publications] Kubo S, et al: "High prevalence of infection with hepatitis B and C viruses in patients with hepactocellular carcinoma in Japan"Hepatogastroenterology. 46. 357-359 (1999)
[Publications] Shuto T, et al: "Efficacy of major hepatic hesection for large hepatocellular carcinoma"Hepatogastroenterology. 46. 413-416 (1999)
[Publications] Tamori A, et al: "Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in Japanese patients with hepatitis C virus"Hepatology. 29. 1429-1434 (1999)
[Publications] Shuto T, et al: "Hyperplastic foci as a prognostic factor after resection of hepatocellular carcinoma"Hepatogastroenterology. 46. 2439-2441 (1999)
[Publications] Kubo S, et al: "Clinicul significamce of prior hepatitis B virus infection in patients with hepatitis C virus-related hepatocellular carcinoma"Camcer. 86. 793-798 (1999)
[Publications] Kubo S, et al: "Relationship between multicentric occunemce of hepatocellular carcinoma and histology of noncomcerous hepatic tissue in patients with chonic hepatitis C"Jpn. J. Camcer Res. 90. 2519-2525 (1999)
[Publications] Shuto T, et al: "Post-operative blood tests and multiventric re**rence of hepatocellular carcinoma"Hepatogastroenterology. 46. 2545-2546 (1999)
[Publications] Murase J. et al: "Correlation of clinicopatholofic features of resetred hepatocellular carsinoma with hepatitis C virus genotypes"Jpn. J. Camcer Res. 90. 1293-1300 (1999)
[Publications] Kubo S, et al: "Patterns of and risk factors for re**rence after liver resection for i**ll-defferenti*tal hepatocellular carcinoma: a special reference to multicentric carcinogenesis after operation"Hepatogastroenterology. 46. 3212-3215 (1999)

1999 Fiscal Year Annual Research Report

肝細胞癌多中心性発生の病理学的ならびに分子生物学的診断とその治療成績

Principal Investigator

木下 博明 大阪市立大学, 医学部, 教授 (50047122)

Research Products

[Publications] Kubo, S, et al: "Effects of continuous hepatitis with persistent hepatitis C viremia on outcome after resection of hepatocellular carcinoma"Jpn J Camaer Res. 90. 162-170 (1999)

[Publications] Tanaka H, et al: "Influence of histological inflammatory activity on regenerative capacity of liver after percutaneons troms hepatic portal vein embolization"J. Gastroentaol.. 34. 100-104 (1999)

[Publications] Kubo S, et al: "High prevalence of infection with hepatitis B and C viruses in patients with hepactocellular carcinoma in Japan"Hepatogastroenterology. 46. 357-359 (1999)

[Publications] Shuto T, et al: "Efficacy of major hepatic hesection for large hepatocellular carcinoma"Hepatogastroenterology. 46. 413-416 (1999)

[Publications] Tamori A, et al: "Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in Japanese patients with hepatitis C virus"Hepatology. 29. 1429-1434 (1999)

[Publications] Shuto T, et al: "Hyperplastic foci as a prognostic factor after resection of hepatocellular carcinoma"Hepatogastroenterology. 46. 2439-2441 (1999)

[Publications] Kubo S, et al: "Clinicul significamce of prior hepatitis B virus infection in patients with hepatitis C virus-related hepatocellular carcinoma"Camcer. 86. 793-798 (1999)

[Publications] Kubo S, et al: "Relationship between multicentric occunemce of hepatocellular carcinoma and histology of noncomcerous hepatic tissue in patients with chonic hepatitis C"Jpn. J. Camcer Res. 90. 2519-2525 (1999)

[Publications] Shuto T, et al: "Post-operative blood tests and multiventric re**rence of hepatocellular carcinoma"Hepatogastroenterology. 46. 2545-2546 (1999)

[Publications] Murase J. et al: "Correlation of clinicopatholofic features of resetred hepatocellular carsinoma with hepatitis C virus genotypes"Jpn. J. Camcer Res. 90. 1293-1300 (1999)

[Publications] Kubo S, et al: "Patterns of and risk factors for re**rence after liver resection for i**ll-defferenti*tal hepatocellular carcinoma: a special reference to multicentric carcinogenesis after operation"Hepatogastroenterology. 46. 3212-3215 (1999)

木下博明大阪市立大学, 医学部, 教授 (50047122)

[Publications] Kubo S, et al: "Patterns of and risk factors for rerence after liver resection for ill-defferenti*tal hepatocellular carcinoma: a special reference to multicentric carcinogenesis after operation"Hepatogastroenterology. 46. 3212-3215 (1999)