• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1999 Fiscal Year Final Research Report Summary

Dynamic analysis of intraaneurysmal blood flow using DSA

Research Project

Project/Area Number 10671313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TENJIN Hiroshi  Kyoto Pref.Univ.of Med., assistant professor, 医学部, 講師 (70197820)

Project Period (FY) 1998 – 1999
KeywordsCerebral Aneurysm / Blood Flow / Pig / Human / DSA
Research Abstract

Flow studies are important to understanding pathogenesis and treatment of cerebral aneurysms, but have not been possible in the clinical setting. We have investigated experimentally and clinically intra-aneurysmal bllod flow.
In experiment, we used aneurysms established in and then removed from pigs to compare and correlate flow studies by high-speed video photography of introduced particles and clinically applicable digital subtraction angiography. Mean transit time for contrast in the preparation correlated with video graphically measured particle flow velocity (r=0.616).
In 31 human-aneurysms, aneurysmal blood flow was examined using digital subtraction angiography to determine mean transit time(MTT), the time to peak opacification(PDT) and the time to half-peak(T1/2). Thirty frames per second were acquired and the time density curve was calculated. Regions of interest were drawn on the proximal parent artery, on the distal parent artery, and on the aneurysm itself. In results, MTT of … More the proximal site on the parent artery(P) was 1.82【plus-minus】0.39(second), of the distal site on the parent artery(D) was 2.09【plus-minus】0.51, and of the aneurysm(AN) was 1.91【plus-minus】0.44. PDT of P was 1.39【plus-minus】0.31, of D was 1.56【plus-minus】0.37, and of AN was 1.53【plus-minus】0.38. T1/2 of P was 0.64【plus-minus】0.26, of D was 0.93【plus-minus】0.53, and of AN was 0.83【plus-minus】0.52. MTT of small aneurysm(Sm) was 1.86【plus-minus】0.42, and of large aneurysm(L) was 2.09【plus-minus】0.52. MTT of small aneurysm(Sm) was 1.86【plus-minus】0.42, and of large aneurysm(L) was 2.09【plus-minus】0.52. PDT of Sm was 1.45【plus-minus】0.30, and of L was 1.81【plus-minus】0.53(P=0.23). T1/2 of Sm was 0.75【plus-minus】0.31, and of L was 1.16【plus-minus】0.77(P=0.38). In conclusion, intra-aneurysmal blood flow small aneurysms was similar as that in the parent artery, consequently the central stream strikes the aneurysmal wall. Intra-aneurysmal blood flow in large aneurysms was slower than that in small ameurysms. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Hiroshi Tenjin: "Evaluation of intra-aneurysmal blood velocity by time density curve using digital subtraction angiography"AJNR Am J Neuroradiol. 19. 1303-1307 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 天神博志: "脳神経血管内手技 (Interventional Neuroradiology) 103回の経験"京都府医大誌. 107. 805-813 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumio Asakura: "Evaluation of intra-aneurysmal blood folw : Investigation of the flow in experimental aneurysm"Intervantional Neuroradiology. 4(supple 1). 77-80 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 正木裕人: "DSAを用いた実験動脈瘤の血流速度測定"京都府医大誌. 107. 587-591 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 天神博志: "Coil塞栓術による脳動脈瘤内血流の変化"脳神経外科速報. 9. 819-823 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumio Asakura: "Difital subtraction and conventional blood flow studies in porcine experimental aneurysms"Interventional Neruoradiology. 5. 207-212 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 酒江けんじ: "脳底動脈先端部動脈瘤の1症例"脳卒中の外科. 27. 130-133 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tenjin H, Asakura F, Nakahara Y, Matsumoto K, Matsuo T, Urano F, Ueda S: "Evaluation of intra-aneurysmal blood velocity by time density curve using digital subtraction angiography."AJNR Am J Neuroradiol. 19. 1303-1307 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tenjin H, Ueda S. Kakita K, Kubo S, Muzukawa N, Ohta T, Uchibori M, Sekimoto T, Yamamoto K: "One hundered three cases of intervantional neuroradiology."J Kyoto Pref Med. 107. 805-813 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asakura F, Tenjin H, Matsumoto K, Uedo S: "Evaluation of intra-aneurysmal blood flow : Investigation of the flow in experimental aneurysm."Interventional Neuroradiology. 4(supple). 77-80 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masaki H, Tenjin H, Asakura F, Matsumoto K, Ueda S: "Blood velocity in experimental aneurysm"J Kyoto Pref Med. 107. 587-591 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tenjin H, Asakura F, Masaki H, Mataumoto K, Matsuo T, Urano M, Ueda S: "Blood flow change induced by coil embolization"Neurosurgical letter. 9. 819-823 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tenjin H, Asakura F, Nakahara Y, Matsumoto K, Matsuo T, Urano F, Ueda S: "Evaluation of intra-aneurysmal blood velocity by time density curve using digital subtraction angiography."Stroke. 29(supple). 311 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asakura F, Tenjin H, Matsumoto K, Ueda S, Urano M: "Digital subtraction and conventional blood flow studies in porcine experimental aneurysms."Interventional Neruoradiology. 5. 207-212 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2001-10-23  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi