2000 Fiscal Year Final Research Report Summary
Significance of soluble Fas and its related cytokines in serum of rheumatoid arthritis patients.
| Project/Area Number |
10671352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
TAKEUCHI Shoji Gifu University, School of Medicine Professor, 医学部, 教授 (50021473)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Toshiko Fukui Medical University, School of Medicine Associate Professor, 医学部, 助教授 (30242746)
SAITOH Kunio Gifu University, School of Medicine Assistant Professor, 医学部・附属病院, 講師 (80262765)
SEISHIMA Mitsuru Gifu University, School of Medicine Professor, 医学部, 教授 (10171315)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Rheumatoid arthritis / Apoptosis / Soluble Fas / Cytokine |
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| Research Abstract |
Increase of soluble Fas (sFas) have been reported in some inflammatory disease such as rheumatoid arthritis (RA), and has some destructive functions of the joints.
The aim of this study is to assess the relationship between the sFas and its related cytokines in patient with rheumatoid arthritis.
The subjects consisted of 46 RA patients and 155 voluntary healthy subjects. Stage of the patients is stage I (6 cases), II (4), III (21), IV (15). RF and CRP concentrations were measured by LPIA.IL-6, IL-8, sIL-2R concentrations were determined by ELISA.sFAS concentrations was determined by Seishima's method (Clin, Chem, 42 : 1911〜1941, 1996).
sFas concentrations in RA was higher than controls (RA : 3.62±1.01ng/ml, controls : 2.12ng/ml, p<0.001).
There were no significant differences in sFas among each stage and CRP of RA.In contrast, there were significant correlations between sFas and sIL-2R (r=0.567, P<0.001).
These results suggested that sFas might play an important role in RA.
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