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2000 Fiscal Year Final Research Report Summary

The Study of Histomorphometric Measurement, Cytokine Expression and Bone Metabolic Markers Gene Polymorphism in Hemodialysis Patients

Research Project

Project/Area Number 10671389
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

KATO Yoshiharu  Faculty of Medicine, Tokyo Women's Medical University, 医学部, 助教授 (00143850)

Co-Investigator(Kenkyū-buntansha) WADA Hiroyoshi  Faculty of Medicine, Tokyo Women's Medical University, 医学部, 助手 (80287416)
ITOH Shunichi  Faculty of Medicine, Tokyo Women's Medical University, 医学部, 助手 (10307580)
Project Period (FY) 1998 – 2000
KeywordsRenal failure / Hemodialysis / Bone histomorphometry / Renal Osteodystrophy / Interleukin-1β / Destructive Spondyloarthropathy / β2-microglobulin / Gene Polymorphism
Research Abstract

We evaluated 51 chronic renal failure and hemodialysis patients, who had orthopaedic surgery, by bone morphometry, cytokine expression and gene polymorphism. In bone morphometry these patients were histologically classified into three groups ; and osteitis fibrosa type, aplastic type, and osteomalacia type. Osteitis fibrosa demonstrates high turnover bone, and typical characteristic X-ray findings (rugger-jersy appearance etc.). In destructive spondyloarthropathy (DSA) patients aplastic type is more than osteitis fibrosa type and osteomalacia type. In RT-PCR cytokine studies IL- 1 β was clearly expressed in only osteitis fibrosa group (high turnover bone), and not control and other types. This finding indicates that this cytokine induce cell differentiation, growth and activity of bone forming cells in high turnover bone. We postulated that amyloid deposit (β2-microglobulin) may be responsible for the induction of DSA, and spinal osteoporosis may be responsible for the progression of DSA.We examined apoprortein E gene polymorphism type and vitamin D receptor gene polymorphism for gene predisposition of DSA.In DSA patients E3/3 type (72.5%) in apoprortein E gene polymorphism type and bb type (64.7%) in vitamin D receptor gene polymorphism are most frequent than other types, and the patients with E3/3 and bb may be related to DSA onset and progression.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 加藤義治: "透析アミロイドーシス:予防と治療-整形外科的治療"腎と透析. 47巻. 831-836 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤義治,金谷幸一: "慢性腎不全のすべて:腎移植-特発性大腿骨頭壊死"腎と透析. 49巻. 519-523 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤義治: "整形外科手術の周術期管理-透析患者手術の周術期管理"別冊整形外科. 40巻(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤義治: "糖尿病性腎症の治療-合併症をどう扱うか:骨病変"中外医学社 青木三千雄 佐中孜 編集. 184

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshiharu Kato: "Orthopaedic complications in dialysis-associated amyloidosis patients"Kidney and Dialysis. Vol47-6. 831-836 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshiharu Kato: "Idiopathic osteonecrosis of the femoral head"Kidney and Dialysis2000. Vol49. 519-523 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kohichi Kanaya: "amyloidosis patients"Kidney and Dialysis2000. Vol49. 519-523 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshiharu Kato: "Perioperative management in orthopaedic surgery for hemodialysis patients"Orthopaedics. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshiharu Kato: "Orthopaedic complications- Bone Lesion"Care of patient with Diabetic nephropathy Chugai Med. Co.. 132-136 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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