1999 Fiscal Year Final Research Report Summary
A new concept of MAC - MAC for airway occlusion response (MAC AOR)
| Project/Area Number |
10671401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Chiba University |
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Principal Investigator |
IDE Tohru Chiba Univ., Sch. of Med., Dept. of Anesthesiology, Assistant Professor, 医学部, 助手 (70213022)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Inhalational Anesthetics / Anesthetic Depth / Noxious Stimulus / Respiratory Distress |
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| Research Abstract |
1. We have demonstrated that airway occlusion can be noxious stimulus and can induce a measurable motor response depending on the depth of inhalational anesthesia in cats. Based on this phenomenon, we have introduced the concept of MAC-AOR.
2. Using our animal model with airway occlusion during inhalational anesthesia, we found that lung expansion reduces the tolerable limit to airway occlusion and vagotomy decreased minimum alveolar anesthetic concentration for airway occlusion, which suggests that pulmonary vagal afferents play an important role in relief of respiratory distress.
3. Inhalational furosemide also reduced the torelable limit to airway occlusion.
4. Thoracic epidural anesthesia reduced the respiratory distress induced by airway occlusion. This effect is most likely caused by the systemic effect of lidocaine, not by the decreased afferent information from the chest wall.
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