2000 Fiscal Year Final Research Report Summary
Investigation on upper airway collapsibility and postoperative nocturnal breathing in children
| Project/Area Number |
10671402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Chiba University |
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Principal Investigator |
ISONO Shiroh Chiba University, School of Medicine, Assistant, 医学部, 助手 (80212968)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Respiration / Upper airway / Airway obstruction / Children / Development / Body position / Prone position / Postoperative |
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| Research Abstract |
The purposes of this investigation were to assess prevalence and significance of late post-operative nocturnal desaturations caused by upper airway obstruction in small children, and to compare upper airway collapsibility in small children with adults. While we failed to complete the study on post-operative nocturnal desaturations because of unreliable measurements of oxygen saturation in these small children, we completed the evaluation of pharyngeal collapsibility in small children under general anesthesia with muscle paralysis. We found that infants had more collapsible pharynx than adults, and the pharyngeal airway was stabilized within the first year of life. Most interestingly, prone position increased the pharyngeal collapsibility in infants and small children. Our findings indicate that maturation and body position significantly contribute to post-operative nocturnal breathing abnormality. Furthermore, increased pharyngeal collapsibility by the prone position may give a key evidence for the higher prevalence of SIDS victims. Because our study was performed under general anesthesia with total muscle paralysis, we lack knowledge on a role of neuromuscular mechanisms compensating the upper airway obstruction. Future studies should be directed to investigate contribution of the neuromuscular mechanisms in these small children.
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