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2001 Fiscal Year Final Research Report Summary

Effects of Intravenous anesthetics on Phosphatidylinositol Response of Spinal Descending Inhibitory Pathways of Rat

Research Project

Project/Area Number 10671421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagasaki University

Principal Investigator

SHIBATA Osamu  University Hospital, Nagasaki University, Associate Professor, 医学部・附属病院, 助教授 (80136671)

Project Period (FY) 1998 – 2000
KeywordsSpinal cord / Intravenous anesthetics / Inositol monophosphate / Phosphatidylinositol response
Research Abstract

Noradrenergic neurons arise from the locus coeruleus and project widely to the spinal cord, cerebral cortex andothers. Noradrenergic pathways in the spinal cord are considered to be one of the central descending inhibitory influences on spinal sensory transmission. Norepinephrine (NE) in the central nervous system has the effect to stimulate phosphatidylinositol (PI) response through aradrenergic receptors. The present study was designed to examine the effects of intravenous anesthetics on NE-induced PI response of rat spinal cords. Materials and Methods: Male Wistar ratsweighing 250-350 g were used for the experiments. , The rats were anesthetized with pentobarbital and their thoracic spinal cord was rapidly isolated. The spinal cord waschopped into 1-mm-wide slices. Three pieces of the slice were placed in small flat-bottomed tubes andincubated in K-H solution containing 5 mM LiCI. The effects of intravenous anesthetics on NE-induced inositol monophosphate (IP_1) accumulation were examined. We measured [^3H]IP_1 in spinal cord slices incubated with [^3H]myo-inositol with aliquid scintillation counter. Results : NE-induced IP_1 accumulation of spinal cord slices was attenuated dose-dependently by droperidol, but was not attenuated by ketamine, fentanyl and midazolam.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Osamu Shibata: "There is no direct relationship between PI response and smooth muscle contraction of rat trachea stimulated by α agonists"Canadian Journal of Anesthesia. 48. 830-831 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Atsushi Tsuda: "A dose-response study of anticholinesterase drugs on contractile and phosphatidylinositol responses of rat trachea"Anesthesia Analgesia. 92. 100-105 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Osamu Shibata: "Clonidine attenuates the carbacole-induced contractile and phosphatidylinositol responses of rat trachea"Journal of Pharmacy and Pharmacology. 52. 1523-1528 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shu Iwanaga: "The role of α_1-adronoceptors in clonidine-induced contraction and relaxation of rat aorta"Research Communications in Molecular Pathology and Pharmacology. 102. 137-147 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shibata O, Saitgo M, Maekawa T, Shibata S, Makita T, Sumikawa K: "There is no direct relationship between PI response and smooth muscle contraction of rat trachea stimulated by alpha-agonists"Can J anaesth. 43(8). 830-1 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuda A, Shibata O, Saito M, Hashimoto S, Iwanaga S, Makita T, Sumikawa K: "A dose-response study of anticholinesterase drugs on contractile and phosphatidylinositol responses of rat trachea"Anesth Analg. 92(1). 100-5 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shibata O, Saito M, Hashimoto S, Sakai K, Makita T, Sumikawa K: "Clonidine attenuates the carbachol-induced contractile and phosphatidylinositol responses of rat trachea"J. Pharm Parmacol. 52(12). 1523-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwanaga S, Shibata O, Tsuda A, Hashimoto S, Makita T, Cho S, Sumikawa K: "The role of alpha1 - adrenocedptors in the clonidine-induced contraction and relaxation of rat aorta"Res Commun Mol Pathol Pharmacol. 102(2). 137-47 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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