1999 Fiscal Year Final Research Report Summary
Research for pre-operative assessments of autonomic function to pick up risk factors influencing intra-operative hemodynamic variances
| Project/Area Number |
10671423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHIMODA Osamu Kumamoto University Hosp. Asso.Professor, 医学部・附属病院, 講師 (40187480)
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA Hiroyoshi Kumamot University Hosp. Asiss.Professor, 医学部・附属病院, 助手 (90264308)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Intra-operative hemodynamic / risk factor / assessment of autonomic function / skin vasomotor reflex / power spectral analysis / baro-reflex sensitivity |
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| Research Abstract |
We evaluated pre-operative autonomic functions in 78 patients for elective surgery using (1) the amplitude of skin vasomotor reflex (SVmR-amplitude) induced with inspiratory gasp, (2) spontaneous baroreflex sensitivity (SBRS), (3) power spectral analysis of heart rate variability (PSA-HRV) and (4) power spectral analysis of blood pressure variability (PSA-BPV). These parameters were compared with values of blood pressure and heart rate during general anesthesia. Furthermore, the SVmR-amplitude was evaluated under various anesthetic conditions with various intensities of electrical stimuli. The summary of results is described below.
1) Depth of anesthesia and the SVmR-amplitude indicate inverse proportion if intensity of stimuli was constant
2) Intensity of stimuli and the SVmR-amplitude had proportional relationship if depth of anesthesia was constant.
3) Patients with diabetes and hypertension sometime indicated normal autonomic functions detected above-mentioned tests.
4) Patients who had normal SVmR-amplitude indicated small intra-operative hemodynamic variance. Inversely, patients who had small SVmR-amplitude occurred large intra-operative hemodynamic variance.
5) The SVmR-amplitude had no correlation with intra-operative bradycardia, but correlated roughly with intra-operative tachycardia.
6) Intra-operative variance of heart rate correlated roughly with the SBRS, but had no correlation with PSA-HRV.
7) PSA-BPV correlated roughly with the intra-operative variance of blood pressure.
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