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1999 Fiscal Year Final Research Report Summary

The systematic study of aging change of micturition.

Research Project

Project/Area Number 10671465
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionShinshu University

Principal Investigator

ISHIZUKA Osamu  Shinshu University Hospital, Assistant Professor, 附属病院, 講師 (20184541)

Co-Investigator(Kenkyū-buntansha) IGAWA Yasuhiko  Shinshu University, Dept. of Urology, Associate Professor, 医学部, 助教授 (40159588)
Project Period (FY) 1998 – 1999
Keywordstachykinins / bladder hyperactivity / rats / bladder cystometry / outlet obstruction / aging / serotonin / adorenalin
Research Abstract

Bladder outlet obstruction, such as benign prostatic hypertrophy, is becoming common disease which causes bladder hyperactivity. This hyperactivity may results from the aging of the nervous control of the micturition. Rats subjected to bladder outlet obstruction show facilitation of bladder reflex mechanisms and several neural changes, including hypertrophy of the dorsal root ganglionic neurons innervating the bladder. Spinal tachykinin receptors and adrenergic receptors have been shown to play a role for micturition, both in normal rats and rats with bladder outlet obstruction. In this study, we could demonstrated that, at the supraspinal level such receptors may also be involved in micturition control. The results implies that supraspinal NK receptors and adrenergic receptors are a possible target for drugs aimed for elimination of bladder hyperactivity secondary to bladder outlet obstruction.
By aging, the nervous control of micturition changes and the mechanism cannot be explained by only adrenergic and parasympathetic nervous control. 5-HT receptors are widely distributed in the central nervous system, including several areas involved in the control of micturition reflex pathways. We studied in normal conscious rats, the effects on the cystometrogram of intracerebroventricular (i.c.v.) administration of 5-HT, an agonist at 5-HT1A receptors, 5-HT2 receptors, 5HT3 receptors and 5-HT4 receptors. The results suggest that, at the supraspinal level, 5-HT (via 5-HT1A, 5-HT2 and 5-HT4 receptors) can enhance the micturition reflex induced by bladder filling. This also means that 5-HT receptor antagonists, acting at 5-HT1A, 5-HT2 and 5-HT4 receptors, can be targets for drugs meant for treatment of bladder hyperactivity, should be explored.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Ishizuka,O., et al.: "Role of supraspinal tachykinins for volume and I-DOPA induced bladder activity in normal conscious rats"Neurourol. Urodynam.. 19・1. 101-109 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gu,B.-J., Ishizuka,O. et. Al.: "Role of supraspinal tachykinins for micturition in conscious rats with and without bladder outlet obstruction"(in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishizuka,O., et al.: "Functional importance of supraspinal α1 adrenergic receptors for micturition in conscious rats with and without bladder outlet obstruction"Neurourol. Urodynam.. 18・4. 391-391 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishizuka,O., et al.: "Roles of central tachykinin receptors for micturition in conscious rats with and without bladder outlet obstruction"Neurourol. Urodynam.. 18・4. 392-392 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komiyama,I., Igawa,Y., Ishizuka,O., et al.: "Effects of intravesical capsaicin and resiniteratoxin on distension-induces bladder contractility in conscious rats with and without spinal cord injury"J. Urol.. 161・1. 314-319 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gu,B.-J., Ishizuka,O., et al.: "Functional importance of central 5-HT receptors for micturition control in normal conscious rats"J. Urol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishizuka, O., Igawa, Y., Nishizawa, O. and Andersson, K.-E.: "Role of supraspinal tachykinins for volume and 1-DOPA induced bladder activity in normal conscious rats."Neurourol. Urodynam.. 19. 101-109 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gu, B.-J., Ishizuka, O., Igawa, Y., Nishizawa, O., Andersson, K.-E.: "Role of supraspinal tachykinins for micturition in conscious rats with and without bladder outlet obstruction."Naunyn-Schmiedeberg's Arch. Pharmacol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishizuka, O., Gu, B.-J., Igawa, Y., Nishizawa, O. and Andersson, K.-E.: "Functional Importance of supraspinal α1 adrenergic receptors for micturition in conscious rats with and without bladder outlet obstruction."Neurourol. Urodynam.. 18. 391 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishizuka, O., Gu, B.-J., Igawa, Y., Nishizawa, O. and Andersson, K.-E.: "Roles of central tachykinin receptors for micturition in conscious rats with and without bladder outlet obstruction."Neurourol. Urodynam.. 18. 392 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komiyama, I., Igawa, Y., Ishizuka, O., Nishizawa, O. and Andersson, K.-E.: "Effects of intravesical capsaicin and resiniferatoxin on distension-induced bladder contractility in conscious rats wit h and without chronic spinal cord injury."J. Urol.. 161. 314-319 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gu, B.-J., Ishizuka, O., Igawa, Y., Nishizawa, O. and Andersson, K.-E.: "Functional importance of central 5-hydroxytryptamine(5-HT) receptors for micturition control in normal conscious rats."J. Urol. Suppl.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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