1999 Fiscal Year Final Research Report Summary
Genetic diagnogis of breast cancer
| Project/Area Number |
10671573
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
EMI Mitsuru Nippon Medical School, Institute of Gerontology, Professor, 老人病研究所, 教授 (90221118)
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Keywords | Uterine myoma / gene fusion / HMGI-C / Chromosome 12 / translocation / COSVIc |
|---|
| Research Abstract |
Cytogenetic analyses have shown that aberrations involving 12q13-15 are frequent chromosomal changes in a variety of human benign mesenchymal tumors, e.g., pleomorphic adenomas of the parotid gland, pulmonary chondroid hamartomas, lipomas, and uterine leiomyomas. Recently, the high-mobility group protein gene HMGIC was identified as the target gene affected by the 12q13-15 aberrations. Using 3' rapid amplification of cDNA ends experiments, we isolated novel ectopic sequences fused to HMGIC in a uterine leiomyoma. Cloning of the fusion cDNA identified the human cytochrome c oxidase subunit Vic (COX6c) gene on 8q22-23 as the fusion partner of HMGIC. Nucleotide sequences of the fusion transcript revealed that the first three exons of the HMGIC gene, encoding the three DNA binding domains, was fused to the exon 2 of the COX6C gene. The identification of a gene rearrangement suggests a role for HMGIC in tumorigenesis of uterine leiomyoma, and suggests a possible involvement of HMGIC in mesenchymal differentiation.
|
Research Products
(12 results)
-
-
-
-
-
-
-
[Publications] I. Kurose, K., Mine, N,m Doi, D., Ota, Y., Yoneyama, K., Konishi, H., Araki, T. & Emi, M.: "Novel Gene Fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a Uterine Leiomyoma."Genes, Chrom. Cancer.. 27. 303-307 (2000)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Publications] Emi M, Yoshimoto M, Sato T, Matsumoto S, Utada Y, Iwase T, Ito I, Minobe K, Tada T, Katagiri T, Bando K, Akiyama F, Harada Y, Fukino K, Sakamoto G, Matsushima M, Iida A, Saito H, Miki Y, Kasumi F. & Nakamura Y: "Allelic loss at 1p34, 13q12, 17q13.3, and 17q21.1 Correlates with Poor Postoperative Prognosis in Breast Cancer."Genes, Chrom. Cancer.. 26. 134-141 (1999)
Description
「研究成果報告書概要(欧文)」より
-
