1999 Fiscal Year Final Research Report Summary
顔面神経の効果的治療法に関する基礎的研究-神経再生における神経内膜の役割の解明-
| Project/Area Number |
10671601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAO Yoshiaki Nagasaki University, assistant Professor, 医学部・附属病院, 講師 (40188884)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Toshimitsu Nagasaki University, Professor, 医学部, 教授 (80133958)
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| Project Period (FY) |
1998 – 1999
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| Keywords | facial nerve / endoneurium / nerve edema / vascular permeability / nerve decompression |
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| Research Abstract |
(1) Using a fluorescent tracer, the extracelluar fluid pathway in the facial nerve and the diffusion of a tracer from the facial nerve to other cranial naves was examined in the rabbit. The endoneurial connective tissue constitutes a diffusion pathway inside the facial nerve fascicles and the extracelluar fluid pathway from the facial nerve to other cranial ganglia may be related to the neural spread of inflammation.
(2) The diffusion barrier from the peripheral nerve trunk to nerve roots was also examined in the rabbit. The diffusion barrier was located where the cranial nerve pierces the dura mater and arachnoid. The absence of efficient diffusion barrier in peripheral ganglia and their location outside the diffusion barrier seems to be related to the pathogenesis of inflammatory lesions.
(3) Facial nerve paralysis such as Bell's palsy or Ramsay Hunt's syndrome is considered to be entrapment neuropathy due to nerve edema. In order to clarify the mechanism of the nerve edema, the vascul
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ar permeability changes after facial nerve injury was examined in the rabbit. Our study revealed an increased accumulation of fluorescent tracer in the entire nerve on the peripheral side, but not on the central side. In the portion with increased intensity, widening of the endoneurial spaces between nerve fibers was observed. Our findings suggested that changes in the interstitial fluid environment following Wallerian degeneration could increase the endoneurial vascular permeability, and this could then cause endoneurial edema.
(4) In order to clarify the mechanism of the nerve edema due to nerve sheath incision during decompression operation of the facial nerve, the nerve sheath of the normal facial nerve was incised in the rabbit. The facial nerve edema was produced immediately after the incision and the endoneurial vascular permeability increased in the edema portion. Our findings suggested that changes in the interstitial fluid environment due to incision of the perineurial diffusion barrier could increase the endoneurial vascular permeability, and this could then cause endoneurial edema. Less
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