2001 Fiscal Year Final Research Report Summary
Prophyractic photocoagulation for serous drusen
| Project/Area Number |
10671661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nihon University |
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Principal Investigator |
YUZAWA Mitsuko Dept. of Ophthalmology, Nihon University, school of Medicine, Associate Professor, 医学部, 助教授 (60139160)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hiroyuki Dept. of Ophthalmology, Nihon University, school of Medicine, Assistant Professor, 医学部, 講師 (40162680)
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| Project Period (FY) |
1998 – 2001
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| Keywords | soft drusen / choroidal neovascularization / laser photocoagulation |
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| Research Abstract |
We coagulated soft drusen which was strongly suspected of being predisposed to exudative age-related macular degeneration. During the follow-up period, soft drusen in the macular region disappeared in 14 of the 22 eyes (64%) in the study. Choroidal neovascularization was induced in one of these 14 eyes by photocoagulation. Retinal pigment epitheliumchoriocapillaris atrophy in the fovea developed in another of the 14 eyes. This eye had shown pigmentary change before this foveal atrophy occured We also followed up 98 eyes of 89 patients who met the same eligibility criteria but whose soft drusen was not coagulated. Choroidal neovascularization appeared in 11 eyes (11 %). Accumulative incidence was estimated to be 3% at one year, 39% at three years, and 64% at five years. Although the incidence of developing CNV in untreated eyes is high, the photocoagulation which we performed seems an inappropriate treatment for patients with soft drusen.
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