1999 Fiscal Year Final Research Report Summary
Development of detachable silicone balloon for fetal tracheal occlusion
| Project/Area Number |
10671666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | University of Tokyo |
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Principal Investigator |
ITOH Mitsuhiro University of Tokyo, Faculty of Medicine, Assistant, 医学部・附属病院, 助手 (40261995)
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| Co-Investigator(Kenkyū-buntansha) |
KITANO Yoshihiro University of Tokyo, Faculty of Medicine, Assistant, 医学部・附属病院, 助手 (30261994)
KOZUMA Shirou University of Tokyo, Faculty of Medicine, Associate professor, 医学部・附属病院, 助教授 (10272569)
HASHIZUME Kohei University of Tokyo, Faculty of Medicine, professor, 医学部・附属病院, 教授 (50180815)
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| Project Period (FY) |
1998 – 1999
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| Keywords | fetal surgery / diaphragmatic hernia / endoscopic surgery |
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| Research Abstract |
In this study, we have shown that insertion of a detachable, cyllinder-shaped silicone balloon to the fetal trachea is feasible in pregnant sheep. The balloon stayed inside the trachea for 1-2 weeks in 6 out of 7 fetal lambs. The effect of tracheal occlusion by this custom made balloon on fetal lung growth was as remarkable as that induced by tracheal ligation or clipping. The hysterotomy required for the balloon insertion was as small as 1 cm. This approach is clinical beneficial because it is minimally invasive to the pregnant uterusand is potentially reversible by ultrasound guided puncture of the balloon. However, the tracheal malacia was seen in all of the trachea-occluded animals. Finer selection in the balloon size is mandatory to avoid this serious complication.
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