2001 Fiscal Year Final Research Report Summary
Degeneration, regeneration, and transplantation of nerve and muscle
| Project/Area Number |
10671693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | OKAYAMA UNIVERSITY (2000-2001)
Kawasaki Medical School (1998-1999) |
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Principal Investigator |
KOSHIMA Isao Okayama University, Graduate School of; Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (60101804)
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| Project Period (FY) |
1998 – 2001
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| Keywords | muscle degeneration / muscle regeneration / Pacinian corpuscle / myoblast / myotube / established facial paralysis / vascularized nerve graft / muscle transfer with neurovascular pedicle |
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| Research Abstract |
Morphological changes of de- and reinnervated Pacinian corpuscles
After denervation of the sciatic nerve, terminal axon of the corpuscles degenerated but outer core exist without degeneration. After reinnervation of the nerve, several terminal axons appeared in the corpuscle.
Muscle de- and regeneration of transferred muscle
After degeneration of muscle, original muscle fibers degenerated to form myobtubes which were developed from myoblasts. After regeneration of thses myotubes, musle cells became normal cytoskeletons.
Clinical investigations of vascularized nerve grafts and vascularized muscle grafts
Clinical usefulness of free vascularized deep peroneal nerve grafts for longer nerve gaps over 20 cm were proved in the cases with brachial plexus palsy. One-stage transfer of free vascularized rectus femoris and abdominis muscle grafts with longer femoral and intercostal motor nerves were clinically proved useful for cases with established facial palsies.
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