1999 Fiscal Year Final Research Report Summary
Cell injury in the central nervous system and calcium mobilization
| Project/Area Number |
10671744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NISHIKAWA Takashige Kagoshima University, Faculty of Dentistry, Professor, 歯学部, 教授 (10034191)
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Yoshiko Kagoshima University, Faculty of Dentistry, Research Associate, 歯学部, 助手 (60185973)
TANAKA Koh-ichi Kagoshima University, Faculty of Dentistry, Research Associate, 歯学部, 助手 (30274848)
SATO Tomoaki Kagoshima University, Faculty of Dentistry, Research Associate, 歯学部, 助手 (10284887)
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| Project Period (FY) |
1998 – 1999
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| Keywords | brain cell injury / calcium / vasopressin fragment / hydrogen peroxide / estrogen / memory / learning / DNA repairment |
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| Research Abstract |
Three summaries obtained in this financial support were as follows.
1) Role of ryanodine receptors in hydrogen peroxide-induced DNA fragmentation and thymidine incorporation cultured rat astrocytes.--- We examined hydrogen peroxide (HィイD22ィエD2OィイD22ィエD2)-induced DNA fragmentation and thymidine incorporation into cultured astrocytes as an indicator of the process of recovery from astrocytic DNA injury, and results obtained suggest that the process of recovery from astrocytic DNA injury by HィイD22ィエD2OィイD22ィエD2 may be regulated by CaィイD12+ィエD1 efflux from ryanodine- sensitive intracellular CaィイD12+ィエD1 stores.
2) The ameliorating effects of a novel NC-1900 on impairments of learning/memory caused by glutamic acid---The effects of a vasopressin fragment analog NC-1900 were studied on learning and/or memory impairment in passive avoidance task and on cell damage of cultured cerebro-cortical neurocytes induced by glutamic acid, and results obtained suggest that NC-1900 may serve as a remedies in various patients with certain brain disorders induced by excess glutamic acid.
3) Effects of ovariectomy and calcium deficiency on learning and memory of eight-arm radial maze in middle-aged female rats.---We examined the effect of ovariectomy and low-calcium diet on learning and memory, middle aged female Wistar rats were fed either a low-calcium or a normal-calcium diet, and results obtained suggest that ovariectomy and low-calcium diet may impair learning and memory and that the combination of these factor produced a more marked impairment.
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