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1999 Fiscal Year Final Research Report Summary

The Molecular Mechanism of Late Phase Adverse Reaction of Contrast Media

Research Project

Project/Area Number 10671772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionKagoshima University

Principal Investigator

NOIKURA Takenori  Kagoshima University, Faculty of Dentistry, Professor, 歯学部, 教授 (40102561)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Ikuro  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (20082282)
Project Period (FY) 1998 – 1999
KeywordsAdverse reaction / Late phase / Endothelial cells / P-selectin / NF-kappa B / nitruc oxide / iNOS / Contrast media
Research Abstract

Endothelial Selectins, such as P-selectin and E-selectin, mediate cell adhesion of monocytes or neutrophils to activated endothelial cells. Previously we reported an upregulated expression of inflammatory cytokines by P-selectin-mediated neutrophil attachment to activated endothelium stimulated by contrast media.
We examined the effect of endothelial selectins on the expression of inflammatory cytokines, nitric oxide production and on the activation of NF-kappa B. We found that the soluble forms of P-selectin and E-selectin as well as the monocyte-endothelial interaction induced upregulated the expression of inflammatory cytokines and the production of nitric oxide. These expression of inflammatory cytokines involved the activation of NF-kappa B pathway by the reactive oxygen intermediate (ROI). P-selectin specifically induced β2-integrin (CD11b)-mediated sticky adhesion of monocytes, via ROI generation. Then P-selectin-mediated rapid activation of NF-kappa B, which was augmented by following with β2-integrin (CD11b)-induced sticky adhesion. The binding of endothelial selectins to monocytes in the area of vascular activation by contrast media is considered to be a component of the mechanism that initiates thrombosis and hypotension after the administration of contrast media.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nakata. M, Maruyama. I: "Leptin Promotes Aggregation og Human Platelets via the Long Form of Its Receptor"DIABETES. 48. 426-429 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakashima M, Maruyama I: "A novel recombinant soluble thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers"J. Clin. Pharmacol.. 38. 540-544 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] Matsushita Y., Maruyama I: "A subcloned human esophageal squamous cell carcinoma cell line with low thrombomodulin expression showed increased invasiveness compared high thrombomodulin expressing clone-thrombomodulin as a possible candidate for an adhesion molecule ofsquamous cell carcinoma"Cancer Lett. 127. 195-201 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] Nishi J, Maruyama I: "Difference in incidence and transmission mode of methicillin-resistant Staphylococcus aureus among surgery, orthopedics, and pediatrics words: a prospective study at a university hospital"Infect. Control. Hosp. Epidemiol.. 19. 107-109 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] Nakata M., Maruyama, I: "DX9065X, an Xu inhibitor, inhibits prothrombin-induced A549 lung adenocarcinoma cell proliferation"Cancer Lett. 122. 127-133 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maruyama I: "Recombinant thrombomodulin and activated protein C in the treatment of dissem intravascular"Thromb Haemost. 82. 718-721 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakata M, Maruyama I.: DIABETES. 48. 426-429 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakashima M, Maruyama I.: J. Clin. Pharmacol.. 38. 540-544 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsushita Y, Maruyama I: Cancer Lett.. 127. 195-201 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishi J, Maruyama I.: Infect. Control. Hosp. Epidemiol.. 19. 107-109 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakata M, Maruyama I: Cancer Lett.. 122. 127-133 (1998)

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  • [Publications] Maruyama I: Thromb Hoemost. 82. 718-721 (1999)

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      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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