Determination of concentration level for antmicrobial heterocyclic metahcrylate monomers for dental use

1999 Fiscal Year Final Research Report Summary

• Project/Area Number: 10671857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Fukuoka Dental College
• Principal Investigator: KAWAGUCHI Minoru Fukuoka Dental College. Dept. of Dental Materials. Research Associate, 歯学部, 助手 (10122780)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Yutaka Fukuoka Dental College. Dept. of Prosthodontics, 歯学部, 助教授 (50154878)
• Project Period (FY): 1998 – 1999
• Keywords: methacrylate / monomer / denture base / relining / antimicrobial activity

Research Abstract

The six kinds of heterocyckic methacrylate monomers were prepared and investigated their antimicrobial activity to Candida albicans. Denture base acrylic resins containing these monomers were subjected to phosphate buffer solution containing C. albicans. The antimicrobial activity of these resins was evaluated from counting the accumulated cells on the resin surface. The results indicated that these heterocyclic monomers, especially imidazole methacrylates, have good antimicrobial activity. Furthermore, we prepared the direct reline materials containing the imidazole methacrylate monomers to apply the denture relining. The results for the reline materials showed same tendency to those for denture base acrylic resins. These results suggested that the imidazole methacrylate monomers would have good potential of antimicrobial activity and be useful to various denture base and reline materials.