1999 Fiscal Year Final Research Report Summary
Regeneration on peri-implant tissues by bone morphogenetic protein
| Project/Area Number |
10671964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ODA Shigeru Tokyo Med. & Dent. Univ., Fac of Dent. Lecturer, 歯学部, 講師 (70160869)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Atsuhiro Tokyo Med. & Dent. Univ., Fac of Dent. Instructor, 歯学部, 助手 (10242207)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Bone Morphogenetic Protein / BMP / Implant / Dog / Osseointegration |
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| Research Abstract |
The objective of this study was to investigate regeneration on peri-implant tissues (bone, connective tissue and epithelium) following installation of fixtures with application of recombinant human bone morphogenetic protein-2 (rhBMP-2).
All mandibular premolars of 6 beagle dogs were extracted. After 3 month of healing, apical 5 mm of 10 mm fixtures (Bronemark System【encircledR】, length : 10 mm, diameter : 3.75 mm) were installed in bilateral edentulous bone ridges. RhBMP-2(0.4 mg/ml) with polylactic acid polyglycolic acid copolymer / gelatin sponge (PGS) was applied to cover the coronal half of the fixture in the experimental side. In the opposite side of the mandible, the coronal half of the fixture was covered with PGS alone. RhBMP-2 and PGS were supplied by Yamanouchi Pharmaceutical Co., Ltd.. Three months after installation, the dog was sacrificed. Immediately, the implant regions were dissected and fixed. Undecalcified sections were prepared. Radiographs were taken every two weeks.
Postoperative swelling was observed in the experimental group. Radiographs after 3 months revealed that a large amount of bony tissue regenerated in the experimental group, while the bone height in the control group was almost the same as compared to pre-surgery.
In the experimental group, bone regeneration was significantly greater than in the control group (p<0.01, paired t-test). Furthermore, the epithelial downgrowth in the experimental group was inhibited significantly as compared with the control group (p<0.01, paired t-test).
The results of this experiment suggest that recombinant human bone morphogenetic protein-2 (rhBMP-2) may enhance tissue regeneration on peri-implant tissue around the fixture.
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Research Products
(15 results)
