1999 Fiscal Year Final Research Report Summary
On the mechanism in nifedipine induced gingival overgrowth
| Project/Area Number |
10671974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
SHIRAKI Masafumi School of Dentistry, Associate Professor, 歯学部, 助教授 (70121324)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Nifedipine / Gingival Overgrowth / Glycos aminoglycan |
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| Research Abstract |
The analysis of glycosaminoglycan (GAG) was studied in nifedipine induced gingival overgrowth in rats. Specific pathogen free Fischer rats were used. Experimental rats were given a diet containing nifedipine at 250mg/kg diet (NF250), and at 500mg/kg diet (NF500). Control rats were fed the same diet without nifedipine. The GAG extracted from control, NF250 and NF500 gingival samples were separated by cellulose acetate membrane electrophoresis for both qualitative and quantitative analysis. 3 groups gingiva contained much higher amounts of hyaluronic acid (HA), dermatan sulfate (DS) and lower amounts of heparan sulfate (HS), chondroitin sulfate (CS). HA and DS were increased significantly in NF250 and NF500. HA and DS may be related to the nifedipine induced gingival overgrowth. These findings suggest the biochemical response of GAGs in nifedipine induced gingival overgrowth in rats might by different from that in normal gingiva.
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