2000 Fiscal Year Final Research Report Summary
SYNTHETIC SUTUDIES ON BIOACTIVE MARINE PRODUCT, BISINDOLE PIPERAZINE ALKALOID AND ITS RELATED COMPOUNDS
| Project/Area Number |
10672006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | MEIJI PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
SAKAMOTO Masanori MEIJI PHARMACEUTICAL UNIVERSITY, FACULTY OF PHARMACY, PROFESSOR, 薬学部, 教授 (70087774)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Tomomi MEIJI PHARMACEUTICAL UNIVERSITY, FACULTY OF PHARMACY, ASSOCIETE PROFESSOR, 薬学部, 助教授 (70161304)
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| Project Period (FY) |
1998 – 2000
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| Keywords | dragmacidin / 3-indolinone / Wittig reaction / indolylglycine / diketopiperazine / optically active ylide |
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| Research Abstract |
We have studied on total syntheses of biologically active marine products, (±)-dragmacidins using our original methodology that includes condensation of a couple of indolylglycines, cyclization to diketopiperazine and reduction of diketopiperazine. Consequently we established the general method for synthesis of indolylglycines and succeeded in total syntheses of (±)-dragmacidins A-C Further we developed generally synthetic method for opticaly active indolylglycines. Our initial objects are achieved by our studies in this term, and constructed the base of further development in this area.
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