1999 Fiscal Year Final Research Report Summary
Functions of Networks and Control of Drug Delivery Due to Interaction Between Gel Networks and Solutes
| Project/Area Number |
10672022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
YONESSE Masakatsu Nagoya City University, Department of Pharmaceutical Chemistry, Professor, 薬学部, 教授 (00080218)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Isamu Nagoya City University, Department of Pharmaceutical Chemistry, Instructor, 薬学部, 助手 (70137123)
SATO Shizuko Nagoya City University, Department of Pharmaceutical Chemistry, Assistant Professor, 薬学部, 講師 (70080207)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Hyaluronate Gel / Alginate Gel / Controlled Releases / Cationic surfactants / Amphiphilic Solutes |
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| Research Abstract |
This research was directed toward elucidating the effects of interactions between gel matrices and amphiphilic solutes on the control of the delivery, and toward the development of novel DDS.
Hyaluronate-hydroxyethyl acrylate (HA-PHEA) interpenetrating hydrogels were prepared as matrices for controlled release devices from glycidyl methacrylate HA and HEA. The swelling -deswelling behavior was reproducible and HA-PHEA gels were found to be useful recycle ones. Interactions between amphiphilic solutes and the HA-PHEA gel matrices were found to shrink them and the releases of the solutes to be suppressed significantly. Their releases were controlled by adding external chemical signals such as the changes of ionic strengths and pH. However, as increasing their hydrophobic interactions, physical factors were found to become important to control the release.
To progress the control of the solute releases due to the interactions, effects of external forces on the releases should be studied further.
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