1999 Fiscal Year Final Research Report Summary
The chemical properties and the tumorigenic effects of the peroxy radicals induced by photolysis
| Project/Area Number |
10672113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
YAMANAKA Kenzo Nihon University, College of Pharmacy, Associate Professor, 薬学部, 講師 (50182572)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Peroxy radical / Skin tumorigenesis / Tumor promotion |
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| Research Abstract |
I demonstrated that dimethylarsenic peroxy radical ((CHィイD23ィエD2)ィイD22ィエD2AsOO・) was formed by the photolysis of (CHィイD23ィエD2)ィイD22ィエD2AsI under an aerobic condition and that the chemical properties of the peroxy radicals. In the present study, I examined the effects of the peroxy radicals on skin-tumorigenic process in hairless mice.
The results obtained are mentioned below.
1. The application of (CHィイD23ィエD2)ィイD22ィエD2AsI and ultraviolet B (UVB) to the skins of hairless mice did not induce initiation activity in skin tumorigenesis, but induced strong promotion actibity. Thus, the result supports that dimethylarsenic peroxy radicals themselves have promotion activity.
2. A result suggests that the promotion mechanisms of the peroxy radicals are different from those of UVB.
3. To elucidate the effects of promotion and progression by the peroxy radicals, in vitro system using Balb c3T3 clone A31-1-1 cells was established. The promotion and progression activities by the peroxy radicals were detected by the in vitro system, similarly by mouse in vivo system.
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