2000 Fiscal Year Final Research Report Summary
Relevance Between Apoptosis And Ratio of Bax/Bcl-2 in Cancer Cells
| Project/Area Number |
10672185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | SHOWA UNIVERSITY |
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Principal Investigator |
KAETSU Sachiyo School of Medicine, SHOWA UNIVERSITY assistant, 医学部, 助手 (40255766)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Yasusi School of Medicine, SHOWA UNIVERSITY subprofessor, 医学部, 助教授 (30138490)
GOMI Kunihide School of Medicine, SHOWA UNIVERSITY professor, 医学部, 教授 (60053980)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Bcl-2 / Bcl-XL / Bax / APOPTOSIS / p53 / Bad / PKB / AKT / caspase 3 / cisplatin |
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| Research Abstract |
Bax and Bad is known as proapoptotic protein. When they are heterodimerized with Bcl-2 or Bcl-XL which s known as anti-apoptotic protein, apoptosis is proceed. But when cells are receaved with some stress of proliferation, Bax and Bad are separated and Bcl-2/Bcl-XL are made anti-apoptotic homodimerizons, cells are proliferated. Our study 1) detection of Bcl-2 family protein and mRNA, p53 protein and caspase 3, 2) When we use anti-cancer drugs, we analuzed Bcl-2 family protein using cell line.
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