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2000 Fiscal Year Final Research Report Summary

Relevance Between Apoptosis And Ratio of Bax/Bcl-2 in Cancer Cells

Research Project

Project/Area Number 10672185
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionSHOWA UNIVERSITY

Principal Investigator

KAETSU Sachiyo  School of Medicine, SHOWA UNIVERSITY assistant, 医学部, 助手 (40255766)

Co-Investigator(Kenkyū-buntansha) TAKAGI Yasusi  School of Medicine, SHOWA UNIVERSITY subprofessor, 医学部, 助教授 (30138490)
GOMI Kunihide  School of Medicine, SHOWA UNIVERSITY professor, 医学部, 教授 (60053980)
Project Period (FY) 1998 – 2000
KeywordsBcl-2 / Bcl-XL / Bax / APOPTOSIS / p53 / Bad / PKB / AKT / caspase 3 / cisplatin
Research Abstract

Bax and Bad is known as proapoptotic protein. When they are heterodimerized with Bcl-2 or Bcl-XL which s known as anti-apoptotic protein, apoptosis is proceed. But when cells are receaved with some stress of proliferation, Bax and Bad are separated and Bcl-2/Bcl-XL are made anti-apoptotic homodimerizons, cells are proliferated. Our study 1) detection of Bcl-2 family protein and mRNA, p53 protein and caspase 3, 2) When we use anti-cancer drugs, we analuzed Bcl-2 family protein using cell line.

  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] K.Fukuchi, et al.: "DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells"Biochimica et Biophysica Acta. 1404. 405-411 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Fukuchi, et al.: "Direct proteasome inhibition by clastolactacyastin β-lactone permits the detection of ubiquitinated p21^<waf1> in ML-1 cells."Biochimica et Biophysica Acta. 1451. 206-210 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Fukuchi, et al.: "DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells"Biochimica et Biophysica Acta. 1404. 405-411 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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