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2000 Fiscal Year Final Research Report Summary

The relationship between physical activity and anti-oxidant capacity

Research Project

Project/Area Number 10680023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionNagoya Institute of Technology

Principal Investigator

OHKUWA Tetsuo  Department of Technology, Nagoya Institute of Technology, Assitant Professor, 工学部, 助教授 (80115675)

Co-Investigator(Kenkyū-buntansha) NAOI Makoto  Department of Brain Sciences, Nagoya Institute of Technology, President, 脳科学部門, 部長 (50022786)
Project Period (FY) 1998 – 2000
KeywordsHydroxyl radical / Reduced glutathione / Voluntary running / γ-glutamyl transferase / γ-glutamylcystein synthetase / Development / Vitamin E supplementation / Muscle damage
Research Abstract

「In 1998 and 1999」A negative correlation was observed between the hydroxyl radical level in liver and the running distance, whereas reduced glutathione level in liver positively correlated with the distance. In addition, the acdvities of glutathione reductase and superoxide dismutase in liver positively correlated with the hydroxyl radical level, suggesting that the anti-oxidant capacity might be induced in consequence of oxidative stress. These results suggest that with higher inducible anti-oxidant capacity may tolerate severer physical exercise, and vice versa rats with higher physical activity may induce higher anti-oxidant capacity. Moreover, it was demonstrated that the endurance training reduced the basal level of hydroxyl radicals significantly in plasma and soleus muscle. In liver and brain a similar tendency was observed, but the differences was not statistically significant. In liver the basal level of GSH increased significantly after training. Slower training with longer duration reduced the basal levels of hydroxyl radical in plasma more markedly than more intense training. These results suggest that endurance training exercise can increase the anti-oxidative capacity in rats. 「In 2000」We observed that the anti-oxidant capacity increases during a selective period in growth, and that voluntary exercise augments the increased at this stage of growh. The effects of exercise on the induction of anti-oxidant capacity should be carefully evaluated, taking consider the effects of growth as shown here. In human study, furthermore, it was cleared that vitamin E supplementation can reduce the leakage of creatine kinase and lactate dehydrogenase activity following the 6 successive days of endurance running. The protective effect of vitamin E against free radicals probably inhibits free-radical-induced muscle damage caused by a sudden large increase in the running distance.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Hiroshi Itoh: "Vitamine E supplementation attenuate leakage of enzymes following 6 successive days of running training"Int.J.Sports Med.. 21. 369-374 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本貴子: "自発的運動によるトレーニングが抗酸化機能の誘導ラットの週齢および運動期間との関連"東海保健体育科学. 22. 17-24 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Itoh: "Effects of endurance training on hydroxyl radical generation"Life Sciences. 63(21). 1921-1929 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuo Ohkuwa: "Induction of anit-oxidant capacity ; effects of rat's age and exercise period"International conference of sports biomechanics. (口頭発表). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Itoh: "Daily physical activity increase anti-oxidant capacity in elderly women"6^<th> Annual Congress of the European College of Sports Science. (口頭発表). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本貴子: "Peroxynitrite(ONOO)による細胞内タンパクの酸化とアポトーシスの誘導"日本基礎老化学会 第23回大会講演要旨集. 24(1)(口頭発表). 46 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itoh, H.Ohkuwa, T., Ymamoto, T., Sato, Y., Naoi, M.: "Effects of endurance training on hydroxyl radical generation in rats."Life Science. 63(21). 1921-1929 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh, H., Ohkuwa, T., Ymamamoto, T.et al.: "Vitamine E supplementation attenuate leakage of enzymes following 6 successive days of running training."Int J.Sports Med. 21. 369-374 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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